ESTIMATES OF HERITABILITY COEFFICIENTS IN FEMALE RHESUS MACAQUES

雌性恒河猴遗传系数的估计

• 批准号: 8358106
• 负责人: Hans Michael Kubisch
• 金额: $ 3.72万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358106
• 关键词: Age; Animal Model; Birth; Birth Intervals; Cessation of life; Data; Daughter; Female; First Births; Funding; Genetic; Grant; Heritability; Infant; Longevity; Macaca mulatta; Methods; National Center for Research Resources; Parents; Postpartum Period; Primates; Principal Investigator; Productivity; Reporting; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; cost; male; programs; reproductive; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Introduction: We have expanded our study to determine heritability coefficients of a number of reproductive parameters of captive female rhesus macaques (Macaca mulatta) to include phenotypic and genetic correlations. Methods: The data used to estimate heritability coefficients and phenotypic correlations contained 7,829 births, 1,898 females and 1,227 grand dams. Infants were born from 1982 through 2007. The MTDFREML animal model program was used to estimate heritability. Because no male parents were identified, the numerator relationship matrix contained all females involving maternal half-sib and daughter-dam relationships. Reproductive traits included female age at the birth of the first, second and last infant, age at death, inter-birth intervals, number of infants born per female and infant survival. Results/Discussion: Heritability estimates were generally small, ranging from 0.000 ¿ 0.072 for postpartum birth interval following the birth of the first infant to 0.325 ¿ 0.143 for a female's age at death. Estimates for heritability for female longevity traits and for productivity were moderate in size and larger than for most reproductive traits. Phenotypic correlations varied from near zero to 0.900 (P 0.01) between number of infants born and dam age at death. Genetic correlations were small with large standard errors. The heritability estimates reported here appear reasonable and tend to be similar to those for reproductive traits in other species.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 简介：我们已经扩大了我们的研究，以确定遗传系数的繁殖参数的圈养雌性恒河猴（猕猴），包括表型和遗传相关性。 方法：用于估计遗传力系数和表型相关的数据包括7，829名新生儿，1，898名女性和1，227名母鼠。婴儿出生于1982年至2007年。MTDFREML动物模型程序用于估计遗传力。由于没有确定男性父母，分子关系矩阵包含所有女性涉及母亲半同胞和女儿-母亲的关系。生殖特征包括第一个、第二个和最后一个婴儿出生时的女性年龄、死亡年龄、出生间隔、每名女性出生的婴儿数量和婴儿存活率。 结果/讨论：遗传力估计值通常较小，从第一个婴儿出生后的产后生育间隔的0.000 <$0.072到女性死亡年龄的0.325 <$0.143不等。女性长寿性状和生产力的遗传力估计是中等大小，大于大多数生殖性状。 出生婴儿数量与死亡年龄之间的表型相关性从接近零到0.900（P 0.01）不等。遗传相关性小，标准误差大。这里报告的遗传力估计似乎是合理的，往往是类似于其他物种的生殖性状。