NOVEL IMMUNOTOXIN AND IGF THERAPY FOR STRABISMUS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在美国出生的儿童中，至少有3%患有斜视或眼睛错位。未矫正的婴幼儿斜视会导致视功能丧失。该项目的目标是开发与发育性或获得性斜视相关的眼肌疾病的新疗法。我们的方法是评估有前景的调整眼肌力量的新治疗方案。我们已经将包括胰岛素样生长因子(IGF-I)和骨形态发生蛋白(BMP-I)在内的生长因子缓释微丸应用于猕猴的眼肌，取得了显著的进展。例如，我们已经发现，IGF-I在处理过的幼猴肌肉中产生了显著的和选择性的眼肌生长。我们还证明，我们可以改变人工诱导斜视猴子的眼线。去年，我们的研究取得了很大进展，在华南理工大学建立了一个新的实验室，并与P.I.S一起从耶克斯华侨大学转到华南理工大学。如果我们的研究成功，我们的研究可能会为治疗与斜视相关的欠作用或过度作用的肌肉提供一种手术的替代方案。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. At least 3% of children born in the United States is afflicted with strabismus or misaligned eyes. Left untrearted infantile strabismus will lead to loss of visual function. The goal of this project is to develop novel treatments for eye muscle disorders associated with developmental or acquired strabismus. Our approach is to evaluate promising new treatment options for adjusting eye muscle strength. We have made significant progess using slow-release growth factor pellets including insulin-like growth factor (IGF-I) and Bone Morphogenic protein (BMP-I) placed on eye muscles of macaques. For example, we have found the IGF-I produces significant and selective eye muscle growth fro treated muscles of infant monkeys. We have also demonstratred that we can alter eye alignment of monkeys with artificially induced strabismus. Setting up a new laboratory at WaNPRC in association with the P.I.'s move from Yerkes NPRC to WaNPRC has been a major part of the progress during the last year. If successful our studies could provide an alternative to surgery for treating under or over-acting muscles associated with strabismus.