Expansion & Improvement of Nonhuman Primate Caging at the WaNPRC

摘要 华盛顿国家灵长类研究中心(WaNPRC)提供基础设施和研究支持 用于大量使用非人灵长类动物(NHP)作为人类模型的生物医学研究项目 疾病。目前的住房指导方针、法规和标准要求研究机构提供社会保障 为所有NHP提供住房，除非有科学或兽医豁免。上的许多研究方案 WaNPRC允许社会住房，其他允许社会互动，至少在研究的一部分 而不会影响实验结果。由于以下几个因素，NHP的社会化可能具有挑战性 和设施限制。为了应对这些挑战，我们设计了一种创新的模块化笼具系统 这是足够灵活的，以促进中心的NHP住房的社会化。然而，没有足够的 这些新的模块化笼子的数量，为目前正在研究的动物和我们的 为设施扩建提供资金。因此，这项建议寻求支持购买额外的笼子以符合 新的要求。新的NHP笼子将取代旧式笼子，并为我们的 我们的西部设施和拟建的ARC大楼的预定翻新。为了增加我们的持有量 容量和合规性，我们需要购买许多新的笼子。这笔赠款将允许IS 购买50个模块化不锈钢灵长类增殖器(100个笼子)。该提案特别要求 购买27个第3组机架单元(54个保持架)和23个第4组机架单元(46个保持架)。这笔资金来自于 该提案将极大地增强我们为关键生物医学提供更多猕猴的社交场所的能力 研究项目。

ABSTRACT The Washington National Primate Research Center (WaNPRC) provides infrastructure and research support for a large number of biomedical research projects utilizing nonhuman primates (NHP) as models for human disease. Current housing guidelines, regulations and standards require that research facilities provide social housing for all NHPs unless there are scientific or veterinary exemptions. Many of the research protocols at the WaNPRC allow for social housing and others allow for social interactions at least for a portion of the study without compromising experimental outcomes. Socialization of NHP can be challenging due to several factors and facility constraints. To address the challenges, we have designed an innovative modular caging system that is flexible enough to facilitate socialization of NHP housed at the center. However, there are insufficient numbers of these new modular cages to provide social housing for animals currently on study and for our funded facility expansions. Therefore, this proposal seeks support to purchase additional caging to comply with the new requirements. The new NHP caging will replace old-style cages and provide additional cages for our scheduled renovation of our Western facility and the proposed ARC building. In order to increase our holding capacity and compliance with regulation, we need to purchase many new cages. This grant would allow is to purchase 50 modular stainless steel primate enrichment units (100 cages). The proposal specifically requests the purchase of 27 Group 3 rack units (54 cages) and 23 Group 4 rack units (46 cages). Funding from this proposal would greatly enhance our ability to socially house additional macaques for critical biomedical research projects.