STUDIES OF VISUAL PROCESSING & SMOOTH EYE MOVEMENTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的研究是针对定义与平稳追踪眼球运动和凝视相关的视觉处理的神经基质。 我们正在努力定义早期视觉体验与眼动系统、眼动定位和凝视保持发展之间的关系。 视觉和眼神经系统在出生时还不成熟。 如果早期的视觉体验受到损伤或先天性缺陷的影响，那么眼动障碍可能会随之而来，从而影响清晰的视觉。 在过去的一年中，我们已经取得了重大进展，证明视觉运动处理过程中增强积极扫视行为。在我们的发展研究中，我们已经证明，至少有一些顺利的追求在区MST斜视受试者优先响应，只有一只眼睛。 这种病理状态可能与斜视患者在平滑追踪中的鼻向偏向有关。我们目前的研究正在研究在发展过程中的皮质平滑追踪系统的可塑性程度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our studies are directed at defining the neural substrate for visual processing related to smooth pursuit eye movements and gaze-holding. We are working to define the relationship between early visual experience and development of eye movement systems, eye alignment and gaze-holding. The visual and oculomotor systems are not mature at birth. If early visual experience is compromised by injury or congenital defect, eye movement disorders can follow that can compromise clear vision. During the last year we have made significant progress demonstrating that visual motion processing is enhanced during active saccadic behavior. In our developmental studies, we have demonstrated that at least some smooth pursuit neurons in area MST of strabismic subjects respond preferentially for only one eye. This pathological condition may be related to the nasalward bias in smooth pursuit in strabismic subjects. Our current studies are examining the degree of plasticity in the cortical smooth pursuit system during development.