NEURAL CONTROL OF VISUAL VESTIBULAR BEHAVIOR

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 正常的姿势、平衡和稳定的视觉依赖于视觉和前庭系统之间的相互作用。我们的研究旨在确定正常视觉-前庭-眼球运动行为的神经底物。由于前庭系统的正常发育或损伤，一直需要校准前庭眼反射的运动输出。如果没有这种校准，就会出现在运动过程中保持平衡和清晰视力的困难。除了长期校准外，视觉还由瞬间或动态的视觉-前庭相互作用来支持。我们最近已经证明，MST和FEF中的神经元在意志凝视运动中对获得控制具有不同的贡献。我们使用目标扰动来说明在跟踪过程中，FEF中的神经元比MST中的神经元对目标扰动更敏感。我们正在努力发现在支持凝视控制的皮质-桥脑-小脑通路的不同组成部分中处理的信号。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Normal posture, balance and stable vision are dependent on interactions between the visual and vestibular systems. Our studies are directed at defining the neural substrate for normal visual-vestibular-oculomotor behavior. There is a continuous need to calibrate the motor output of the vestibular ocular reflex due to normal development or injury to the vestibular system. Without this calibration, difficulties in maintaining balance and clear vision during locomotion would occur. In addition to long-term calibration, vision is supported by moment-by-moment or dynamic visual-vestibular interactions. We have recently demonstrated that neurons in MST and FEF have differential contributions to gain control during volitional gaze movements. We used target perturbation to demonstrate the neurons in the FEF are more sensitive to target perturbation during tracking then those neurons MST. We are working to uncover the signals processed in different components of the cortical-ponto-cerebellar pathways supporting gaze control.