STRUCTURE FUNCTION ANALYSIS OF C-GROUP MOTONEURONS

C组运动神经元的结构功能分析

• 批准号: 8357632
• 负责人: Michael J Mustari
• 金额: $ 15.66万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357632
• 关键词: Development; Disease; Eye; Eye Movements; Funding; Grant; Knowledge; Motor Neurons; Muscle Fibers; National Center for Research Resources; Peripheral; Primates; Principal Investigator; Relative (related person); Research; Research Infrastructure; Resources; Role; Source; Strabismus; Structure; United States National Institutes of Health; cost; gaze

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Treatment and cure of developmental or acquired strabismus requires advancing our knowledge about how eye alignment and eye movements are controlled at peripheral levels. Our studies will compare and contrast the functional organization and relative roles of different classes of motoneurons (C- and A-groups) that primarily drive either orbital or global eye muscle fibers, respectively. Completion of our studies could significantly advance our understanding of normal and pathological eye alignment, gaze-holding and eye movement associated with strabismus and other disorders.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 发育性或后天性斜视的治疗和治愈需要我们进一步了解眼睛的排列和眼球运动是如何在周边水平控制的。 我们的研究将比较和对比不同类别的运动神经元（C-和A-组）的功能组织和相对作用，主要驱动眼眶或全球眼肌纤维，分别。 我们的研究的完成可以显着推进我们的理解正常和病理性的眼睛对齐，凝视和眼球运动与斜视和其他疾病。