STRUCTURE FUNCTION ANALYSIS OF C-GROUP MOTONEURONS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 发育性或获得性斜视的治疗和治愈需要我们进一步了解眼球对齐和眼球运动是如何在外周水平上控制的。我们的研究将比较和对比不同类别的运动神经元(C组和A组)的功能组织和相对作用，这些神经元分别主要驱动眼眶或全球眼肌纤维。完成我们的研究可以显著提高我们对与斜视和其他障碍相关的正常和病理性眼球对齐、凝视和眼球运动的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Treatment and cure of developmental or acquired strabismus requires advancing our knowledge about how eye alignment and eye movements are controlled at peripheral levels. Our studies will compare and contrast the functional organization and relative roles of different classes of motoneurons (C- and A-groups) that primarily drive either orbital or global eye muscle fibers, respectively. Completion of our studies could significantly advance our understanding of normal and pathological eye alignment, gaze-holding and eye movement associated with strabismus and other disorders.