NEURAL CONTROL OF VISUAL-VESTIBULAR BEHAVIOR

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这个项目的目标是确定不同的大脑皮质神经元中携带的信息，这些神经元投射到桥核，产生眼睛和头部(凝视)的运动。我们的目标是顶区(MST)和额叶(FEF)的神经元，这些神经元已经被发现使用逆行激活技术投射到DLPN或NRTP。一旦确定了投射神经元，我们就使用多变量统计模型来确定每个神经元和与凝视运动相关的人群中携带的信息。我们发现，在FEF-NRTP和MST-DLPN通路中传递的与凝视相关的信号有很大的差异。与P.I.一起在WaNPRC建立一个新的实验室是去年进展的一个主要部分。S从耶克斯NPRC转移到WaNPRC。确定皮质-桥脑-小脑系统中不同节点的功能贡献将有助于推进我们对健康和疾病中凝视控制的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to define the information carried in different cerebral-cortical neurons that project to pontine nuclei to produce eye and head (gaze) movements. We are specifically targeting neurons in parietal area (MST) and the frontal lobe (FEF) that have been identified as projecting to the DLPN or NRTP using the technique of antidromic activation. Once a projection neuron is identified we use multi-variate statistical modeling to determine the information carried in each neuron and in populations related to gaze movements. We have discovered that there are major differences in gaze-related signals that travel in FEF-NRTP and MST-DLPN pathways. Setting up a new laboratory at WaNPRC in association with the P.I.'s move from Yerkes NPRC to WaNPRC has been a major part of the progress during the last year. Determining the functional contribution of different nodes in the cortical-ponto-cerebellar system will aid in advancing our understanding of gaze control in health and disease.