Animal Holding Area Expansion in Support of AIDS-Related Research at the WaNPRC

扩大动物饲养区以支持 WaNPRC 的艾滋病相关研究

• 批准号: 8658202
• 负责人: Michael J Mustari
• 金额: $ 99.91万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-26 至 2017-06-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8658202
• 关键词: Acquired Immunodeficiency Syndrome; Animal Housing; Animals; Area; Biomedical Research; Commit; Complement; Containment; Funding; Housing; Operative Surgical Procedures; Primates; Recommendation; Research; Research Personnel; Research Project Grants; Subfamily lentivirinae; Universities; Washington; design; guide for the care and use of laboratory animals; improved; nonhuman primate; programs; square foot

The Washington National Primate Research Center (WaNPRC) has supported AIDS-related research projects for more than 25 years. These projects are performed at the Western facility, where the vivarium is designed to house nonhuman primates at an ABSL-2 containment level with enhanced containment practices implemented for lentivirus research. The AIDS-related research program is expanding with the addition of new core staff, funding of new projects for existing core staff, and new collaborative efforts between core staff and external investigators. With a projected increase in animal numbers, a need to upgrade cage wash facilities, and a need to expand surgical capabilities for upcoming projects, the University of Washington has committed $5.6 million to expand the vivarium by approximately 2500 square feet at the WaNPRC Western facility, install a new cage-wash/autoclave facility and build a state-of-the-art surgical suite for the support of AIDS-related research. We are requesting additional funding to convert the current surgical area into animal housing and to build out additional area within the expanded vivarium space for animal holding. The proposed animal holding rooms will accommodate 80 Group four (10-15 kg) nonhuman primates, or more smaller animals. The rooms will be constructed in accordance with the recommendations of the eighth edition of the Guide for the Care and Use of Laboratory Animals. The completion of the animal holding space will synergistically complement the institutionally-funded project to upgrade the cage-wash facilities and surgical suite, and will improve and increase our ability to conduct biomedical research, especially AIDS-related research.

华盛顿国家灵长类动物研究中心(WaNPRC)支持艾滋病相关研究项目已超过25年。这些项目是在西方的设施中进行的，在那里，隔膜被设计成以ABSL-2遏制水平容纳非人类灵长类动物，并为慢病毒研究实施了增强的遏制实践。艾滋病相关研究计划正在扩大，增加了新的核心工作人员，为现有核心工作人员提供了新的项目资金，并在核心工作人员和外部调查人员之间进行了新的合作努力。随着动物数量的预计增加，需要升级笼子洗涤设施，以及需要为即将到来的项目扩大手术能力，华盛顿大学已承诺拨款560万美元，将WaNPRC西部设施的内脏扩大约2500平方英尺，安装新的笼子洗涤/高压灭菌器设施，并建造一套最先进的外科套件，以支持艾滋病相关研究。我们正在申请更多资金，将目前的手术区改造为动物收容所，并在扩大的空间内建造更多区域，供动物收容。拟建的动物拘留室将容纳80个第四组(10-15公斤)非人类灵长类动物，或更多较小的动物。这些房间将按照第八版《保护和使用实验动物指南》的建议建造。动物收容所的建成将协同补充机构资助的升级笼子清洗设施和手术室的项目，并将改善和增加我们进行生物医学研究，特别是与艾滋病相关的研究的能力。