Animal Holding Area Expansion in Support of AIDS-Related Research at the WaNPRC

华盛顿国家灵长类动物研究中心（WaNPRC）支持艾滋病相关研究项目已超过25年。这些项目在西部设施进行，其中动物园旨在以ABSL-2控制水平饲养非人灵长类动物，并为慢病毒研究实施了增强的控制措施。艾滋病相关研究方案正在扩大，增加了新的核心工作人员，为现有核心工作人员的新项目提供资金，以及核心工作人员和外部调查人员之间新的合作努力。随着动物数量的预计增加，需要升级笼清洗设施，以及需要扩大即将到来的项目的手术能力，华盛顿大学已承诺560万美元，以扩大约2500平方英尺的动物饲养场在WaNPRC西部设施，安装一个新的笼清洗/高压灭菌设施，并建立一个国家的最先进的外科手术室，以支持艾滋病相关的研究。我们正在申请额外的资金，将目前的手术区改造成动物饲养区，并在扩大的动物饲养空间内建造额外的动物饲养区。拟议的动物饲养室将容纳80只第四组（10-15 kg）非人灵长类动物或更多较小的动物。将根据第八版实验动物护理和使用指南的建议建造动物室。动物收容空间的建成将协同补充机构资助的项目，以升级笼子清洗设施和手术室，并将改善和提高我们进行生物医学研究的能力，特别是与艾滋病有关的研究。

The Washington National Primate Research Center (WaNPRC) has supported AIDS-related research projects for more than 25 years. These projects are performed at the Western facility, where the vivarium is designed to house nonhuman primates at an ABSL-2 containment level with enhanced containment practices implemented for lentivirus research. The AIDS-related research program is expanding with the addition of new core staff, funding of new projects for existing core staff, and new collaborative efforts between core staff and external investigators. With a projected increase in animal numbers, a need to upgrade cage wash facilities, and a need to expand surgical capabilities for upcoming projects, the University of Washington has committed $5.6 million to expand the vivarium by approximately 2500 square feet at the WaNPRC Western facility, install a new cage-wash/autoclave facility and build a state-of-the-art surgical suite for the support of AIDS-related research. We are requesting additional funding to convert the current surgical area into animal housing and to build out additional area within the expanded vivarium space for animal holding. The proposed animal holding rooms will accommodate 80 Group four (10-15 kg) nonhuman primates, or more smaller animals. The rooms will be constructed in accordance with the recommendations of the eighth edition of the Guide for the Care and Use of Laboratory Animals. The completion of the animal holding space will synergistically complement the institutionally-funded project to upgrade the cage-wash facilities and surgical suite, and will improve and increase our ability to conduct biomedical research, especially AIDS-related research.