NEURAL CONTROL OF VISUAL VESTIBULAR BEHAVIOR

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。正常的姿势、平衡和稳定的视觉依赖于视觉和前庭系统之间的相互作用。我们的研究旨在确定正常视觉-前庭-眼球运动行为的神经底物。由于前庭系统的正常发育或损伤，一直需要校准前庭眼反射的运动输出。如果没有这种校准，就会出现在运动过程中保持平衡和清晰视力的困难。除了长期校准外，视觉还由瞬间或动态的视觉-前庭相互作用来支持。我们在确定DLPN和NRTP在凝视控制中的相对作用方面取得了实质性进展。我们发现在NRTP和DLPN中携带的与眼睛、头部和视觉运动相关的不同信号可以支持凝视行为。我们现在正试图通过在脑桥核、前额眼野和MST区域之间进行逆行激活研究来确定这些信号的来源。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Normal posture, balance and stable vision are dependent on interactions between the visual and vestibular systems. Our studies are directed at defining the neural substrate for normal visual-vestibular-oculomotor behavior. There is a continuous need to calibrate the motor output of the vestibular ocular reflex due to normal development or injury to the vestibular system. Without this calibration, difficulties in maintaining balance and clear vision during locomotion would occur. In addition to long-term calibration, vision is supported by moment-by-moment or dynamic visual-vestibular interactions. We have made substantial progress in defining the relative roles of the DLPN and NRTP in control of gaze. We have found that there are different signals carried in NRTP and DLPN related to eye, head and visual motion that could support gaze behavior. We are now attempting to determine the source of those signals by conducting antidromic activation studies between pontine nuclei, frontal eye fields and MST areas.