VISUAL PROCESSING AND SMOOTH EYE MOVEMENTS

视觉处理和平滑的眼球运动

• 批准号: 8357613
• 负责人: Michael J Mustari
• 金额: $ 15.66万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357613
• 关键词: Brain Stem; Development; Diagnosis; Eye; Eye Movements; Funding; Goals; Grant; Lead; Macaca; Modeling; National Center for Research Resources; Neurons; Ocular Motility Disorders; Pathologic Nystagmus; Primates; Principal Investigator; Research; Research Infrastructure; Research Project Grants; Resources; Role; Smooth Pursuit; Source; Strabismus; United States National Institutes of Health; Visual; cell motility; cost; experience; gaze; improved; infancy; insight; relating to nervous system; visual process; visual processing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purpose of this research project is to consider the role of early visual experience in development of gaze-holding, eye alignment and ocular motility (smooth pursuit). Special emphasis is devoted to cortical and associated brainstem neurons essential for gaze-holding and eye movements of strabismic macaques. The goal is to determine the neural substrate responsible for eye movement disorders such as latent nystagmus, asymmetric smooth pursuit and strabismus associated with impoverished binocular visual experience. We have developed effective macaque models for strabismus, which provide insight into neural correlates related to infantile strabismus that could lead to improved diagnosis and treatments.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本研究的目的是探讨早期视觉经验在注视保持、眼位调整和眼球运动（平滑追踪）发展中的作用。特别强调的是致力于皮层和相关的脑干神经元的斜视猕猴的注视和眼球运动的必要性。我们的目标是确定神经基板负责眼运动障碍，如潜在的眼球震颤，不对称的顺利追求和斜视与贫困的双眼视觉经验。我们已经开发了有效的斜视猕猴模型，它提供了与婴儿斜视相关的神经相关性的见解，可以改善诊断和治疗。