NOVEL IMMUNOTOXIN AND IGF THERAPY FOR STRABISMUS

新型免疫毒素和 IGF 治疗斜视

• 批准号: 8357633
• 负责人: Michael J Mustari
• 金额: $ 15.66万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357633
• 关键词: Eye; Funding; Goals; Grant; Growth Factor; Human; Immunotoxins; Lead; Muscle function; National Center for Research Resources; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; Strabismus; United States National Institutes of Health; Work; cost; efficacy testing; improved; nonhuman primate; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this project is to develop and evaluate novel agents, including growth factors and immunotoxins that could lead to improved treatment options for strabismus. This work is directed at testing the efficacy of growth factors in altering extraocular eye muscle function of non-human primates. The ultimate goal is to be able to apply our results to improve treatment of human strabismus.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该项目的目标是开发和评估新的药物，包括生长因子和免疫毒素，这些药物可能会改善斜视的治疗选择。 这项工作旨在测试生长因子在改变非人灵长类动物眼外肌功能中的功效。最终的目标是能够应用我们的结果来改善人类斜视的治疗。