HIV Evolution, Genomics, and Pathogenesis

HIV 进化、基因组学和发病机制

• 批准号: 8071735
• 负责人: ANDREW D ROBERTSON
• 金额: $ 2.3万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8071735
• 关键词: AIDS/HIV problem; Address; Antiviral Agents; Area; Basic Science; Biological Models; Biology; British Columbia; Canada; Collaborations; Comparative Study; Complex; Critical Pathways; Development; Discipline; Disease Progression; Educational workshop; Environment; Evolution; Genes; Genome; Genomics; Goals; HIV; HIV Infections; Human; Immune response; Immunology; Individual; Infection; Intervention; Knowledge; Left; Melissa; Mentors; Molecular; Outcome; Pathogenesis; Population; Postdoctoral Fellow; Request for Proposals; Research; Research Personnel; Resistance development; Role; Scientist; Shapes; Students; Training; Ursidae Family; Viral; Virus; Virus Latency; Work; World Health; abstracting; career; design; drug development; insight; meetings; novel; novel strategies; novel vaccines; pressure; success; symposium; therapy resistant; transmission process; vaccine development; virology; virus host interaction

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled HIV Evolution, Genomics, and Pathogenesis, organized by Michael Emerman, Melissa Robbiani and Amalio Telenti, which will be held in Whistler, British Columbia, Canada from March 20 - 25, 2011. Elucidating the molecular mechanisms of HIV pathogenesis relies on understanding the complex interplay between the virus and its host. Increasingly, the field is relying on the power of comparative studies of similar viruses in other species and on whole genome analyses to elucidate which pathways are critical to this interplay. The use of evolutionary analyses of both host and virus is also providing novel insights into viral transmission and innate immune responses. This meeting will take advantage of research from diverse disciplines to promote further insights into the dynamic interplay between the virus and the host in areas of pathogenesis, mucosal biology, the roles of viral and host genes, and viral latency. Understanding these issues is critical for the design and development of an effective vaccine and the next generation of antiviral agents. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Protection from HIV: Targeted Intervention Strategies, which will share a keynote address and two plenary sessions with this meeting. Project Narrative: HIV continues to be a major world health problem with tens of millions of individuals infected worldwide. There has been great progress in the development of drugs to treat infection with HIV; however, the virus can develop resistance to these therapies and, consequently, there is still a great need to develop additional therapies to treat infected individuals. The Keystone Symposia meeting on HIV Evolution, Genomics, and Pathogenesis will gather researchers from diverse disciplines to highlight basic research in the study of HIV virology and immunology, and will promote further insights critical for the design and development of an effective vaccine and the next generation of antiviral agents against HIV.

描述(由申请人提供)： 该提案请求支持由Michael Emerman、Melissa Robbiani和Amalio Telenti组织的题为HIV进化、基因组学和致病的Keystone研讨会，该会议将于2011年3月20-25日在加拿大不列颠哥伦比亚省惠斯勒举行。阐明HIV致病的分子机制依赖于了解病毒与宿主之间的复杂相互作用。该领域越来越依赖于对其他物种中类似病毒的比较研究和全基因组分析来阐明哪些途径对这种相互作用至关重要。对宿主和病毒的进化分析的使用也为病毒传播和先天免疫反应提供了新的见解。这次会议将利用来自不同学科的研究，促进对病毒和宿主之间在发病机制、粘膜生物学、病毒和宿主基因的作用以及病毒潜伏期等领域的动态相互作用的进一步深入了解。了解这些问题对于设计和开发有效的疫苗和下一代抗病毒药物至关重要。同时召开的预防艾滋病毒：有针对性的干预战略会议将大大增加跨学科互动的机会，该会议将与本次会议举行一次主旨演讲和两次全体会议。 项目说明： 艾滋病毒仍然是一个主要的世界卫生问题，全世界有数千万人受到感染。在开发治疗艾滋病毒感染的药物方面取得了很大进展；然而，病毒可能对这些疗法产生抗药性，因此，仍然非常需要开发更多的疗法来治疗感染者。关于艾滋病毒进化、基因组和致病的Keystone研讨会会议将聚集来自不同学科的研究人员，突出艾滋病毒病毒学和免疫学研究的基础研究，并将促进对设计和开发有效的艾滋病毒疫苗和下一代抗病毒药物至关重要的进一步见解。