Lipid Biology and Lipotoxicity

描述（由申请人提供）：本提案要求支持由Scott A.萨默斯和鲁道夫Zechner，这将是在基拉尼，有限公司克里，爱尔兰从2011年5月15日至20日举行。脂肪在不适合脂质储存的组织中的积累对器官功能具有有害后果，导致糖尿病、心脏病和高血压的细胞损伤。说明这种关系的事实是，许多有效的治疗剂通过限制外周组织中脂肪的不适当沉积来改善代谢疾病症状（例如，噻唑烷二酮类、二甲双胍或他汀类）。基因组学和脂质组学的最新进展为研究人员提供了一个机会，使他们能够在理解和治疗由脂肪过度产生和/或利用不足引起的致病性疾病方面取得实质性飞跃。本次会议回顾了这些领域，特别强调以下几点：（a）异位脂质沉积和代谢疾病之间的关系;（B）脂质过量改变组织功能的机制;（c）控制脂质储存和代谢的调节过程;以及（d）脂质分析领域的技术进展（即，脂质组学）。关于心血管疾病的专题将深入了解心脏致病事件的病因，许多会议将推进关于脂肪代谢异常与心脏，肺和血液疾病之间的基本关系的知识。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Lipid Biology and Lipotoxicity, organized by Scott A. Summers and Rudolf Zechner, which will be held in Killarney, Co. Kerry, Ireland from May 15 - 20, 2011. The accumulation of fat in tissues not suited for lipid storage has deleterious consequences on organ function, leading to cellular damage that underlies diabetes, heart disease, and hypertension. Illustrating the relationship is the fact that numerous effective therapeutics ameliorate metabolic disease symptoms by limiting the inappropriate deposition of fat in peripheral tissues (e.g., thiazolidinediones, metformin, or statins). Recent advances in genomics and lipidomics offer researchers an opportunity to make a substantial leap in the understanding and treatment of pathogenic conditions resulting from the excessive production and/or underutilization of fat. This meeting reviews these areas, placing specific emphasis on the following: (a) relationships between ectopic lipid deposition and metabolic disease; (b) mechanisms through which lipid excess alter tissue function; (c) regulatory processes that control lipid storage and metabolism; and (d) technological advances in the area of lipid analysis (i.e., lipidomics). Dedicated topics on cardiovascular disease will provide insight into the etiology of pathogenic events in the heart and numerous the sessions will advance knowledge on the fundamental relationships between abnormal fat metabolism and heart, lung, and blood disorders.