MITIGATION OF RADIATION DAMAGE IN MACROMOLECULAR CRYSTALLOGRAPHY EXPERIMENTS

这个子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。次级项目的主要支助 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 为子项目列出的总成本可能 代表子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 基于直线加速器的光源（如LCLS）产生的X射线脉冲比同步加速器短得多，并且通过激光放大，以飞秒量级提供这些非常短的脉冲，每个脉冲具有高度放大的强度。除了提供尺寸小于1微米的射束之外，X射线激光束可以帮助减轻辐射损伤，使得所得衍射图像可以基本上没有辐射损伤。 我们会继续进行这些研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Linac-based light sources like LCLS produce much shorter x-ray pulses than a synchrotron, and with laser amplification, deliver these very short pulses on the order of femtoseconds with a highly amplified intensity per pulse. Beyond providing a beam less than 1 micron in size, the x-ray laser beam may help mitigate radiation damage, such that the resulting diffraction image may be essentially devoid of radiation damage. We will pursue such studies.