RNA Silencing

RNA沉默

• 批准号: 8451773
• 负责人: DAVID L. WOODLAND
• 金额: $ 0.6万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-01 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8451773
• 关键词: Acceleration; Animals; Area; Binding; Biological Models; Biomedical Technology; British Columbia; Canada; Cancer Biology; Cell Nucleus; Cells; Collaborations; Communities; Computer Simulation; DNA Transposable Elements; Data Set; Development; Diagnostic; Disease; Educational workshop; Ensure; Environment; Epigenetic Process; Eukaryota; Exposure to; Faculty; Feedback; Fertilization; Flushing; Functional RNA; Gene Expression; Genetic; Goals; Growth and Development function; Hearing; Human; Left; Link; Malignant Neoplasms; Mediating; Membrane; Mus; Organism; Other Genetics; Outcome; Participant; Plants; Post-Transcriptional Regulation; RNA; RNA Interference; RNA Processing; Regulation; Research; Research Personnel; Resolution; Role; Scientist; Small RNA; Specificity; Staging; Stimulus; System; Therapeutic; Training; Transcriptional Regulation; Work; Zebrafish; abstracting; cell type; clinical application; design; genetic element; graduate student; interdisciplinary approach; interest; meetings; next generation; posters; programs; public health relevance; response; symposium; tool; transcription factor; virology

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled RNA Silencing, organized by David C. Baulcombe and Irene Bozzoni. The meeting will be held in Whistler, British Columbia, Canada from March 19 - 24, 2013. RNA silencing systems are now well established as key components of regulation and control in many eukaryotes including animals and plants. The first flush of discoveries was focused around post- transcriptional regulation. It was anticipated that the small RNA specificity determinants of these silencing systems could be negative switches acting alongside transcription factors control of gene expression during growth, development and responses to external stimuli. More recently the emphasis has shifted. In terms of post-transcriptional regulation, it is now recognized that there are only a few examples in plants and worms in which sRNAs are simple switches. These RNAs are now seen as modulators or fine tuners of post- transcriptional regulation that are often components of negative feedback loops or of control networks in which there are long RNA negative regulators of the sRNAs and secondary sRNAs. The sRNAs can be transported or secreted out of cells and so the RNA mediated control networks may extend beyond one cell. The anticipated potential of sRNA therapeutics has yet to be delivered but they are proving to be a powerful diagnostic tool in cancer and other diseases. A second emerging area is in the link between sRNAs and epigenetic regulation. This link was revealed first from plant work but it is now known in animals in connection with piwi-associated RNAs or piRNAs. These epigenetic sRNAs and piRNAs are certainly important in defense against transposable elements but it is possible that they also influence genetic or epigenetic regulation in other cell types. The 2013 Keystone Symposia meeting on RNA Silencing will focus on these emerging topics of network control systems and epigenetic regulation by various types of sRNA. The program for this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact. The focus on RNA silencing in general provides an umbrella under which speakers from different areas of research (e.g., transcriptional regulation, cancer biology, development, epigenetics and virology) are being brought together in an environment that is highly conducive to cross-talk. Emphasis has also be placed on showcasing early stage investigators presenting on the program with a view to promoting the next generation of scientists in the RNA silencing field.

描述（由申请人提供）：请求支持由David C. Baulcombe和Irene Bozzoni组织的Keystone研讨会会议，标题为“ RNA沉默”。该会议将于2013年3月19日至24日在加拿大不列颠哥伦比亚省的惠斯勒举行。现在在包括动物和植物在内的许多真核生物中，RNA沉默系统已被很好地确立为监管和控制的关键组成部分。第一个发现的冲突集中在转录后调节围绕。预计这些沉默系统的小RNA特异性决定因素可能是负面的转换，与转录因子控制在生长，发育和对外部刺激的反应过程中基因表达的控制。最近，重点发生了变化。在转录后调节方面，现在已经认识到，在植物和蠕虫中只有几个例子，其中SRNA是简单的开关。现在，这些RNA被视为转录后调节的调节剂或微调调节器，这些调节器通常是负反馈回路的组成部分或控制网络的组成部分，其中SRNA和次级SRNA的长RNA负调节剂。 SRNA可以从细胞中运输或分泌，因此RNA介导的对照网络可能延伸到一个细胞之外。 SRNA治疗剂的预期潜力尚未交付，但事实证明它们是癌症和其他疾病的强大诊断工具。 SRNA与表观遗传调节之间的联系中是第二个新兴区域。该链接首先是从植物作品中揭示的，但现在在动物中与PIWI相关的RNA或PIRNA有关。这些表观遗传学的SRNA和PIRNA在防御可转座元件中当然很重要，但是它们也可能影响其他细胞类型的遗传或表观遗传调节。 2013年的关于RNA沉默的Keystone研讨会会议将重点放在各种类型的SRNA的网络控制系统和表观遗传学调节的这些新兴主题上。这次会议的计划很可能会吸引各种各样的调查人员，其中许多人可能不会互动。一般来说，对RNA沉默的重点提供了一个保护伞，其中不同的研究领域的说话者（例如，转录调节，癌症生物学，发育，表观遗传学和病毒学）在非常有利于跨语言的环境中聚集在一起。还强调展示该计划的早期研究人员，以促进RNA沉默领域中的下一代科学家。