Endoderm Lineages in Development and Disease

描述（由申请人提供）：要求支持由Lori Sussel， Hans-Willem E. Snoeck, James M. Wells和Aaron M. Zorn组织的题为“发育和疾病中的内胚层谱系”的Keystone专题会议。会议将于2015年2月8日至13日在科罗拉多州的Keystone举行。内胚层产生大量高度特化的上皮细胞类型，排列在呼吸道和胃肠道上，并对甲状腺、胸腺、肺、肝、胆道系统和胰腺等相关器官有贡献。对内胚层器官发育和产后功能的基础研究揭示了人类先天性疾病的分子基础，发现了新的再生途径，使体外培养内胚层器官组织成为可能。虽然内胚层器官的形式和功能各不相同，但有许多共同的机制支配着这些器官的发育和体内平衡。这次关于内胚层发育和疾病谱系的专题讨论会将重点介绍我们在胚胎发生过程中对内胚层器官发育的理解的最新进展，以及这些知识如何成功地从多能干细胞中产生人类内胚层器官细胞和组织。这次会议的主题完全符合NICHD的使命，即“阐明胚胎发育的生化、分子生物学、遗传和细胞机制，并确定这些过程的功能障碍如何导致出生缺陷和疾病。”

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Endoderm Lineages in Development and Disease, organized by Lori Sussel, Hans-Willem E. Snoeck, James M. Wells and Aaron M. Zorn. The meeting will be held in Keystone, Colorado from February 8-13, 2015. The endoderm gives rise to a vast array of highly specialized epithelial cell types lining the respiratory and gastrointestinal tracts and contributes to associated organs such as thyroid, thymus, lungs, liver, biliary system and pancreas. Basic studies of endoderm organ development and postnatal function have revealed the molecular basis of human congenital diseases, have identified new regenerative pathways, and have made it possible to grow endoderm organ tissues in vitro. While endoderm organs vary in their form and function, there are many shared mechanisms that govern the development and homeostasis of these organs. This Keystone Symposia meeting on Endoderm Lineages in Development and Disease will highlight recent advances in our understanding of endoderm organ development during embryogenesis and how this knowledge has led to successful efforts at generating human endoderm organ cells and tissues from pluripotent stem cells. The topic of this meeting fits perfectly with the NICHD's mission to "elucidate the biochemical, molecular biological, genetic, and cellular mechanisms of embryonic development and determine how dysfunction of each of these processes lead to birth defects and disease."