Tuberculosis Co-Morbidities and Immunopathogenesis

 描述（由申请人提供）：请求对由哈代科恩菲尔德、莎拉M. Fortune和托马斯R.霍恩会议将于2016年2月28日至3月3日在科罗拉多的基斯通举行。结核病仍然是对全球健康的最重大的传染病威胁之一，尽管有效的抗微生物药物已经存在了50多年。这次会议的重点将是作为结核病大流行的主要驱动因素的合并症，包括艾滋病毒/艾滋病，并可能导致免疫力的信息干扰。本次会议将探讨影响结核病宿主-病原体相互作用的代谢紊乱、环境暴露、合并感染、年龄和遗传变异。此外，全体会议将联合收割机，而不是分开，主题集中在主机和病原体，从实验室和现场研究的观点。最后，将鼓励发言者挑战现有的教条，并提供新的范例作为更有效的结核病预防和治疗方法的基础。

 DESCRIPTION (provided by the applicant): Support is requested for a Keystone Symposia meeting entitled Tuberculosis Co-Morbidities and Immunopathogenesis, organized by Hardy Kornfeld, Sarah M. Fortune and Thomas R. Hawn. The meeting will be held in Keystone, Colorado from February 28-March 3, 2016. Tuberculosis remains one of the most significant infectious disease threats to global health despite the availability of effective antimicrobials fo more than 50 years. The focus of this meeting will be on co-morbidities that are major driving factors in the TB pandemic, including HIV/AIDS, and that may cause informative perturbations of immunity. This conference will explore metabolic disorders, environmental exposures, co-infections, age and genetic variants that influence host-pathogen interactions in TB. In addition, plenary sessions will combine, rather than separate, topics focused on the host and the pathogen, and perspectives from laboratory and field studies. Finally, speakers will be encouraged to challenge existing dogma and offer new paradigms as a basis for more effective approaches to TB prevention and treatment.