HIV Persistence: Pathogenesis and Eradication

 说明(由申请人提供)：请求支持由David M.MarGolis、Satya Dandekar和Susana T.瓦伦特组织的题为艾滋病毒持久性：发病机制和根除的Keystone研讨会。会议将于2016年3月20日至24日在加利福尼亚州奥运谷举行。尽管抗逆转录病毒疗法(ART)在临床上取得了成功，但每天新感染艾滋病毒的人比开始抗逆转录病毒疗法的人更多。为艾滋病毒感染者提供终身抗逆转录病毒药物的复杂性使得制定根除艾滋病毒的战略势在必行，或者至少在不进行日常治疗的情况下严格控制病毒。清除逆转录病毒感染是一项艰巨的任务，需要解开病毒持续和宿主免疫相互作用的机制。此外，抗逆转录病毒疗法似乎不能完全减轻艾滋病毒感染对人类健康的影响，需要更好地了解艾滋病毒感染引起的显性和微妙的免疫病理。最近对早期治疗干预和抗艾滋病毒细胞疗法的研究提供了 对制定根除艾滋病毒战略的新见解。本次会议将集中讨论艾滋病毒持久性和根除的所有方面，包括：1)对持续性艾滋病毒感染的理解；2)对逆转录病毒感染的先天防御；3)宿主炎症反应和艾滋病毒发病机制的相互作用；以及4)根除病毒的新概念。将特别注意研究潜伏感染的模型系统的开发进展情况以及消除潜伏感染的战略。重点将放在新的、未发表的发现上，这些发现将突出新的见解和创造性的战略，以开发有效控制和根除艾滋病毒感染的方法。同时召开的艾滋病毒疫苗会议将大大增加跨学科互动的机会，该会议将与本次会议分享主旨演讲和两次全体会议。

 DESCRIPTION (provided by the applicant): Support is requested for a Keystone Symposia meeting entitled HIV Persistence: Pathogenesis and Eradication, organized by David M. Margolis, Satya Dandekar and Susana T. Valente. The meeting will be held in Olympic Valley, California from March 20-24, 2016. Despite the clinical success of antiretroviral therapy (ART), every day there are more people newly infected with HIV than those initiating ART. The complexities of dispensing lifelong ART for HIV-infected individuals make it imperative to develop strategies for HIV eradication, or at least to strictly control the virus without daily therapy. The clearance of a retroviral infection is a herculean task and requires unraveling the mechanisms of viral persistence and host immune interactions. Further, ART does not appear to completely mitigate the impact of HIV infection on human health, and a better understanding of the overt and subtle immune pathologies induced by HIV infection is needed. Recent studies of early therapeutic interventions and HIV-resistant cellular therapies have provided new insights into the development of HIV eradication strategies. This meeting will focus on all aspects of HIV persistence and eradication that include: 1) The understanding of persistent HIV infection; 2) Innate defenses against retroviral infection; 3) The interplay of the host inflammatory response and HIV pathogenesis; and 4) Novel concepts for viral eradication. Special attention will be paid to progress in the development of model systems to study latent infection as well as strategies to eradicate it. Emphasis will be placed on new, unpublished findings that will highlight novel insights and creative strategies to develop effective control an eradication of HIV infection. Opportunities for interdisciplinary interactions will be significantl enhanced by the concurrent meeting on HIV Vaccines, which will share Keynote addresses and two plenary sessions with this meeting.