Stem Cells and Cancer

干细胞和癌症

• 批准号: 8643911
• 负责人: DAVID L. WOODLAND
• 金额: $ 0.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-01 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8643911
• 关键词: Academia; Address; Alberta province; Area; Biological; Canada; Cancer Biology; Cells; Clinic; Clinical; Clinical Trials; Collaborations; Development; Erinaceidae; Generations; Goals; Growth; Growth and Development function; Industry; Invaded; Jordan; Link; Malignant Neoplasms; Metastatic Lesion; Neoplasm Metastasis; Outcome; Pathway interactions; Physicians; Pre-Clinical Model; Process; Relapse; Research; Research Personnel; Role; Scientist; Signal Transduction; Stem Cell Development; Stem cells; Testing; Translations; Work; anticancer research; base; cancer initiation; cancer stem cell; cancer therapy; design; drug development; drug discovery; improved; in vivo imaging; meetings; notch protein; novel strategies; novel therapeutics; posters; pre-clinical; programs; public health relevance; stem cell biology; symposium; tumor progression; tumorigenesis

ABSTRACT Support is requested for a Keystone Symposia meeting entitled Stem Cells and Cancer, organized by Tannishtha Reya, Craig T. Jordan and Philip A. Beachy. The meeting will be held in Banff, Alberta, Canada from February 2-7, 2014. This meeting will bring together leaders in cancer research with the overall goal of defining new pathways and mechanisms that drive oncogenesis and that may be targeted in therapy. In particular, the meeting will examine the links between stem cell development and cancer initiation and progression: how signals active during stem cell development may be reactivated in cancer growth and relapse, the importance of the cell of origin for cancer initiation, and the role of cancer stem cells in cancer propagation. The conference will also address how cancers grow and invade the surrounding microenvironment by highlighting work on in vivo imaging and metastasis. A major objective of the meeting will be to consider these issues in context of translation; key panels will discuss development of better preclinical models of cancer and designing more effective strategies to move basic discoveries to the clinic. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Developmental Pathways and Cancer: Wnt, Notch and Hedgehog, which will share keynote addresses and a plenary session with this meeting. Thus, the program for this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact.

抽象的 请求支持Keystone专题讨论会符合标题为“干细胞和癌症”的keystone专题讨论会，由 Tannishtha Reya，Craig T. Jordan和Philip A. Beachy。会议将在加拿大艾伯塔省的班夫举行 从2014年2月2日至7日开始。这次会议将使癌症研究领导者聚集在一起，总体目标 定义驱动肿瘤发生的新途径和机制，并可能针对治疗。在 特别是，会议将检查干细胞发育与癌症启动与癌症的联系与 进展：干细胞发育过程中的信号如何在癌症的生长和 复发，原始细胞对癌症启动的重要性以及癌症干细胞在癌症中的作用 传播。会议还将解决癌症如何成长和入侵周围环境 微环境通过强调体内成像和转移的工作。会议的主要目标将 在翻译的背景下考虑这些问题；关键面板将讨论更好的临床前的开发 癌症的模型和设计更有效的策略，将基本发现转移到诊所。 跨学科互动的机会将大大增加 发育途径和癌症：Wnt，Notch和Hedgehog，它将共享主题演讲和 这次会议的全体会议。因此，这次会议的计划很可能会吸引各种各样的 调查人员，其中许多可能不会互动。