Institute for Biogenesis Research: COBRE

描述（由申请人提供）：COBRE一期支持使生物发生研究所（IBR）成为生殖生物学研究领域公认的卓越中心。IBR支持教师对人类生殖和生殖生物学相关问题的各个方面的研究。IBR的成功在很大程度上归功于我们教师的科学专业知识和研究兴趣的凝聚力，以及我们在生殖生物学方面的专业知识。我们不断增长的国际认可是由访问教授的评估，NIH小组对我们的初级调查员的选择，一长串的出版物，以及已经获得的资助和奖励所证明的。在前四年获得COBRE支持的五名初级研究人员中，有四名已经将他们的研究发展到可以作为项目负责人的导师或合作者的程度，这些项目负责人将在拟议的第二阶段IBR COBRE中得到支持。在这一申请中，我们寻求加强和改造IBR成为一个多学科的生殖生物学研究中心，它将变得足够独立，能够在外部资助的支持下维持其未来的发展。在第二阶段COBRE资助的未来五年里，我们将专注于扩大我们的研究重点和专业知识，而第一阶段IBR项目负责人将成为研究所更成熟的成员。在第一阶段，中心的教职员工拥有一系列专注于受精和早期发育的实验和科学专业知识，包括广泛的微操作和细胞生物学技术。在第二阶段，我们将显著扩大我们的科学和技术专长，包括下一代测序（NGS）和NGS数据的生物信息学分析。我们认为这对我们的中心来说是一个重要的扩展，我们已经证明了我们在获取NGS数据并将其纳入当前研究项目方面的熟练程度。我们新招募的三位项目负责人熟悉NGS数据的获取，第四位是一位生物信息学家，有分析大型基因组数据库的经验。我们寻求将中心发展成为一个更强大的、自给自足的研究所，拥有广泛的科学专家，可以更有效地竞争中心拨款。我们建议通过以下具体目标来实现这些目标：（SA1）通过四名新研究员的指导来扩大IBR的多学科研究能力。（SA2）通过继续发展IBR教师队伍，并为中心招聘一名高级研究员来加强中心。（SA3）通过扩大转基因小鼠、ICSI和IVF （TMII）核心，加强IBR和该机构的研究基础设施。

DESCRIPTION (provided by applicant): The COBRE Phase I support has allowed the Institute for Biogenesis Research (IBR) to emerge as a recognized center of excellence in the study of reproductive biology. The IBR supports faculty research on various aspects of human reproduction and problems related to reproductive biology. The IBR's success is in large part due to the scientific expertise of our faculty and the cohesion of the research interests, in conjunction with our expertise in reproductive biology. Our growing international recognition is evidenced by assessments given by visiting professors, the selection of our junior investigators to NIH panels, a long list of publications, and that have been grants scored as well as awarded. Four of the five junior investigators who were supported in the first four years of COBRE support have developed their research to the point that they can serve as mentors or collaborators for the Project Leaders who will be supported in the proposed Phase II IBR COBRE. In this application, we seek to strengthen and transform the IBR into a multi-disciplinary reproductive biology research center that will become independent enough to be sustained on extramural grant support for its future development. We will focus on expanding our research focus and expertise during the next five years of Phase II COBRE funding, while the Phase I IBR Project Leaders become more mature members of the institute. The Center faculty in Phase I had a cohesive set of experimental and scientific expertise that focused on fertilization and early development and included a wide range of micromanipulation and cell biology techniques. In Phase II, we will significantly expand our scientific and technical expertise to include next generation sequencing (NGS) and bioinformatic analysis of NGS data. We feel that this is an important expansion for our Center, and we have already demonstrated a proficiency in obtaining NGS data and incorporating it into current research projects. Three of our newly recruited Project Leaders are familiar with obtaining NGS data, and the fourth is a bioinformaticist who has experience in analyzing large genomic databases. We seek to develop the Center into a more robust, self-supporting institute with a wide breadth of scientific expertis that can more effectively compete for center grant funding. We propose to accomplish these goals through the following Specific Aims: (SA1) Expand the multi-disciplinary research capacity of the IBR through the mentoring of four new investigators. (SA2) Strengthen the center through continued development of IBR faculty, and the recruitment of a senior investigator to the center. (SA3) Enhance the research infrastructure of both the IBR and the institution through the expansion of the Transgenic Mouse, ICSI and IVF (TMII) Core.