Frontiers of Structural Biology

描述（由申请人提供）：支持被要求为一个基石研讨会会议，题为结构生物学的前沿，由安德鲁B组织。Ward和韦恩A.亨德里克森会议将于2014年3月30日至4月4日在犹他州雪鸟举行。在结构水平上直接观察生物现象为理解和操纵细胞内的分子相互作用提供了基础，并使诸如基于结构的药物设计等努力成为可能。结构生物学领域现在从原子到细胞的规模上运作，最令人兴奋的研究正在不同技术的界面上进行。因此，重要的是，实践者的各种结构生物学技术走到一起， 并讨论一个更全面的视野。因此，本次会议的目标是连接结构生物学领域的领导者，并评估新的方法和技术。重要的是，会议将突出复杂的细胞生物学的见解所作出的开创性的结构努力（跨多个生物物理学科）和贡献所作出的大规模， 高通量的努力。此外，由于大量的结构信息正在变得可用（并将继续这样做），会议还将突出生物信息学和建模/设计领域的创新，这些领域已经开始利用不断增加的结构信息。因为这次会议汇集了一群采用各种实验技术的结构生物学家，我们的目标是支持前沿进展的传播，并促进充满活力的国际结构生物学社区之间的互动。跨学科互动的机会也将显着提高G蛋白偶联受体的同期会议：结构动力学和功能的影响，这将分享开幕式和闭幕式主旨演讲和全体会议与本次会议。

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Frontiers of Structural Biology, organized by Andrew B. Ward and Wayne A. Hendrickson. The meeting will be held in Snowbird, Utah from March 30 - April 4, 2014. Direct observation of biological phenomena on a structural level provides a basis for understanding and manipulating molecular interactions within a cell and enabling endeavors such as structure based drug design. The field of structural biology now operates on a scale from atoms to cells and the most exciting research is being conducted at the interface of different technologies. Thus, it is important that practitioners of the various structural biology techniques come together and discuss a more holistic view of the field. Therefore, the goals of this meeting are to connect leaders in the structural biology field and to evaluate novel methods and technologies. Importantly, the meeting will highlight complex cell biological insights made by pioneering structural efforts (across multiple biophysical disciplines) and contributions made by large-scale, high throughput efforts. Additionally, because of the large amount of structural information that is becoming available (and will continue to do so) the meeting will also highlight innovations made in areas of bioinformatics and modeling/design that have begun to harness the increasing structural information. Because this meeting brings together a diverse group of structural biologists that employ a variety of experimental techniques we aim to support the dissemination of cutting edge advances and promote interaction among the vibrant international structural biology community. Opportunities for interdisciplinary interactions will also be significantly enhanced by the concurrent meeting on G Protein-Coupled Receptors: Structural Dynamics and Functional Implications, which will share opening and closing keynote addresses and a plenary session with this meeting.