The Crossroads of Lipid Metabolism and Diabetes

脂质代谢与糖尿病的十字路口

• 批准号: 8837760
• 负责人: DAVID L. WOODLAND
• 金额: $ 0.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8837760
• 关键词: Area; Atherosclerosis; Bile Acids; Biochemical; Biochemistry; Cardiovascular Diseases; Cause of Death; Cells; Cellular biology; Cholelithiasis; Cholesterol; Collaborations; Denmark; Development; Diabetes Mellitus; Discipline; Disease; Environment; Epidemic; Faculty; Fatty Acids; Gene Expression; Genetic; Goals; Heart Diseases; Hepatic; High Density Lipoprotein Cholesterol; Hypertriglyceridemia; Immunology; Incidence; Insulin Resistance; Knowledge; Lipids; Lipoproteins; Liver; Metabolic Diseases; Metabolism; Methodology; Microbiology; Molecular Biology; Molecular Genetics; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Pathway interactions; Physicians; Physiology; Postdoctoral Fellow; Prevalence; Process; Production; Research; Research Personnel; Risk Factors; Scientist; Signal Transduction; Touch sensation; Training; Transcriptional Regulation; Underrepresented Minority; abstracting; career; clinical practice; combat; diabetic patient; frontier; graduate student; lipid metabolism; liver transplantation; meetings; multidisciplinary; new therapeutic target; nonalcoholic steatohepatitis; novel; novel diagnostics; novel therapeutics; nutrition; posters; programs; public health relevance; reverse cholesterol transport; symposium; therapeutic target

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled The Crossroads of Lipid Metabolism and Diabetes, organized by Russell A. DeBose-Boyd, Sudha Biddinger and Alan D. Attie. The meeting will be held in Copenhagen, Denmark from April 19-24, 2015. The prevalence of Type 2 diabetes is reaching epidemic proportions throughout the world and increasing the incidence of a variety of related diseases, such as heart disease. One of the key features of these insulin-resistant disorders is disturbance of lipid metabolism. Overproduction of fatty acids in the liver leads to hypertriglyceridemia and low HDL cholesterol, which are important risk factors for the development of atherosclerosis, the most common cause of death among diabetic patients. In addition, excess fatty acid production and the accumulation of hepatic cholesterol promote the development of non-alcoholic steatohepatitis (NASH), which has become one of the leading indications for liver transplantation. Disturbances in bile acid metabolism may also contribute to the development of atherosclerosis, as well as gallstones. The goal of this Keystone Symposia meeting is to provide attendees with the latest advances in the understanding of mechanisms governing the metabolism of lipids and how these pathways become dysregulated in the insulin resistant state. Elucidation of mechanisms underlying lipid metabolism may reveal new therapeutic strategies to combat atherosclerosis and other complications of diabetic patients, such as cardiovascular disease. This program will stimulate interactions that are likely to augment and accelerate this process.

 描述（由申请人提供）：支持被要求为基石研讨会会议题为脂质代谢和糖尿病的十字路口，由罗素A。放大图片作者：DeBose-Boyd，Sudha Biddinger，Alan D.阿蒂会议将于2015年4月19日至24日在丹麦哥本哈根举行。2型糖尿病的患病率在全世界达到流行病的比例，并增加了各种相关疾病如心脏病的发病率。这些胰岛素抵抗性疾病的关键特征之一是脂质代谢紊乱。肝脏中脂肪酸的过度产生导致高胆固醇血症和低HDL胆固醇，这是动脉粥样硬化发展的重要危险因素，动脉粥样硬化是糖尿病患者最常见的死亡原因。此外，过量的脂肪酸产生和肝脏胆固醇的积累促进了非酒精性脂肪性肝炎（NASH）的发展，这已成为肝移植的主要适应症之一。胆汁酸代谢紊乱也可能导致动脉粥样硬化和胆结石的发生。本次Keystone研讨会的目的是为与会者提供有关脂质代谢机制的最新进展，以及这些途径如何在胰岛素抵抗状态下失调。阐明脂质代谢的机制可能会揭示新的治疗策略，以对抗动脉粥样硬化和糖尿病患者的其他并发症，如心血管疾病。该计划将刺激可能扩大和加速这一进程的互动。