Epigenetic and Metabolic Regulation of Aging and Aging-Related Diseases

衰老和衰老相关疾病的表观遗传和代谢调控

• 批准号: 9052432
• 负责人: DAVID L. WOODLAND
• 金额: $ 1.62万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9052432
• 关键词: Address; Age; Aging; Alzheimer' s Disease; Animal Model; Area; Biological Models; Biology; Cardiovascular Diseases; Cells; Collaborations; Diabetes Mellitus; Discipline; Disease; Educational workshop; Environment; Epigenetic Process; Future; Gap Junctions; Genes; Health; Human; Knowledge; Learning; Longevity; Malignant Neoplasms; Medical; Metabolic; Metabolism; Methodology; Neurodegenerative Disorders; New Mexico; Outcome; Predisposition; Process; Regulation; Research; Research Personnel; Risk Factors; Scientist; Stimulus; System; Therapeutic; Translations; United States National Institutes of Health; Work; age related; clinical practice; frailty; frontier; innovation; innovative technologies; interdisciplinary approach; interest; meetings; posters; prevent; public health relevance; symposium; tool; trait

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Epigenetic and Metabolic Regulation of Aging and Aging-Related Diseases, organized by Anne Brunet, David M. Sabatini and Shelley L. Berger. The meeting will be held in Santa Fe, New Mexico from May 1-5, 2016. Aging poses formidable scientific, medical and societal challenges, with old age being the single most important risk factor for a constellation o diseases, including cardiovascular disease, cancer, diabetes and a range of neurodegenerative disorders such as Alzheimer's Disease. Aging is also one of the greatest fundamental mysteries in biology, and arguably its next frontier. Long thought to be inexorable, aging has in fact been shown to be malleable due to specific changes in genes or environment. This meeting will focus entirely on aging, while incorporating a new angle on the emerging nexus between metabolism and epigenetics. The most exciting questions at the forefront of the field will be covered, including: How can external stimuli delay aging in a long-lasting, yet reversible, manner? Does the integration of external stimuli to modulate aging differ among cells with vastly diverse functions? Is aging a synchronous process, and how do the different cells and systems communicate? How do diseases of aging develop, and what can be done to prevent or reverse them?

 描述（由申请人提供）：请求支持由安妮·布鲁内特、大卫M. Sabatini和Shelley L.伯杰会议将于2016年5月1日至5日在新墨西哥州圣达菲举行。老龄化对科学、医学和社会提出了巨大的挑战，老年是一系列疾病的最重要风险因素，包括心血管疾病、癌症、糖尿病和一系列神经退行性疾病，如阿尔茨海默病。衰老也是生物学中最大的基本谜团之一，可以说是它的下一个前沿。长期以来，衰老被认为是不可阻挡的，但事实上，由于基因或环境的特定变化，衰老是有可塑性的。这次会议将完全集中在衰老，同时纳入一个新的角度对新陈代谢和表观遗传学之间的新兴联系。在该领域的最前沿最令人兴奋的问题将被涵盖，包括：外部刺激如何能够以持久但可逆的方式延缓衰老？整合外部刺激以调节衰老在功能差异很大的细胞中是否存在差异？衰老是一个同步的过程吗？不同的细胞和系统如何交流？衰老疾病是如何发展的，可以做些什么来预防或逆转它们？