MEASUREMENT OF DIETARY BIOMAKERS IN EAGeR TRIAL

急切试验中膳食生物制造商的测量

• 批准号: 9575156
• 负责人: MICHAEL TSAI
• 金额: $ 29.2万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-29 至 2019-09-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9575156
• 关键词: 8-hydroxy-2' -deoxyguanosine; Address; Affect; Anti-inflammatory; Aspirin; Biological; Biological Assay; Biological Markers; Calcium; Complex; Data; Data Sources; Diet; Dietary Assessment; Dietary Component; Dietary Fiber; Dose; Double-Blind Method; Exposure to; F2-Isoprostanes; Ferritin; Fertility; Fibroblast Growth Factor; Flavonoids; Folic Acid; Funding; Glycosylated hemoglobin A; Hour; Hydrocortisone; Inflammation; Inflammation Mediators; Interleukin-1; Interleukin-10; Interleukin-6; Interleukin-8; Interleukins; Investigation; Iron; Laboratories; Length; Link; Lipid Peroxidation; Lipid Peroxides; Live Birth; Measurement; Measures; Medical center; Menstrual cycle; Menstruation; Outcome; Ovulation; Oxidative Stress; Participant; Phenols; Phytoestrogens; Placental Growth Factor; Pregnancy; Pregnancy loss; Prolactin; Proteins; Rage; Randomized; Randomized Controlled Trials; Recording of previous events; Reproduction; Research; Role; Sampling; Seminal fluid; Serum; Serum Proteins; Site; TFRC gene; TNF gene; Techniques; Testing; Time; Transferrin; Urine; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factors; Visit; Vitamin B 12; Vitamin D; Vitamin D-Binding Protein; Woman; Work; adiponectin; cost; double-blind placebo controlled trial; environmental chemical; environmental stressor; healthy pregnancy; hepcidin; improved; inflammatory marker; interest; male; novel; pentosidine; pregnant; prospective; protein intake; receptor; repository; reproductive; reproductive hormone; telomere; trial design

The EAGeR trial was a multi-center, block-randomized, double-blind, placebo-controlled trial conducted across four medical centers in the U.S. The Effects of Aspirin in Gestation and Reproduction (EAGeR) Trial is a multi-site, prospective double-blind randomized controlled trial designed to assess the effects of low-dose aspirin in combination with folic acid treatment on pregnancy and gestation among 1228 women with a history of 1-2 pregnancy losses. A large biospecimens repository is available for analysis and offers a good platform for testing multiple hypotheses. This proposal is to request funding through the Biomedical IDIQ mechanism for the measurement of stored biospecimens in the EAGeR Trial. The assays proposed will provide a rich data source on biomarker levels that can be analyzed to answer novel research questions in conjunction with the extensive data already collected in the EAGeR Trial.

EGeR 试验是一项在美国四个医疗中心进行的多中心、分组随机、双盲、安慰剂对照试验。阿司匹林对妊娠和生殖的影响 (EAGeR) 试验是一项多中心、前瞻性双盲随机对照试验，旨在评估低剂量阿司匹林联合叶酸治疗对 1228 名有 1-2 次妊娠史的女性的妊娠和妊娠的影响。损失。大型生物样本库可用于分析，并为测试多种假设提供良好的平台。 该提案旨在通过生物医学 IDIQ 机制申请资金，用于测量 EGeR 试验中存储的生物样本。 拟议的检测将提供有关生物标志物水平的丰富数据源，可以结合 EGeR 试验中已收集的大量数据进行分析，以回答新的研究问题。