GENETIC ANALYSIS OF PEAS SAMPLES 2019

背景和介绍 妊娠期饮食属性研究（PEAS）的目的是检查食物奖励敏感性在妊娠期和产后母亲饮食和体重变化中的作用。该研究考察了食物奖励敏感性与行为控制，家庭食物环境以及饮食行为相关方面的相互作用，这些因素与体重相关的生物医学，心理社会，遗传和行为因素，包括体力活动，压力，睡眠和抑郁症。 不同体重的妇女在怀孕早期被纳入研究，沿着她们的婴儿，直到产后1年。评估发生在怀孕的每个三个月，产后约2个月，6个月，9个月和12个月。母亲的食物奖励敏感性，自我控制，家庭食物环境，饮食行为，饮食摄入，健康行为，人体测量学与母亲和婴儿的临床和生物学数据，婴儿人体测量学和喂养实践一起进行了评估沿着。感兴趣的主要暴露包括食物奖励敏感性、行为控制和家庭食物环境。主要结果包括妊娠期体重增加，产后体重保持和母亲的饮食质量。 在过去的几年里，越来越多的研究发表在探索食物奖励敏感性的神经学和遗传学方面。有趣的是，有许多关于多态性的经证实的报告，这些报告似乎有助于个体对超美味食物的反应的变化。PEAS的研究提供了一个独特的机会，可以在一个大型队列中研究这些问题，并进行大量相关的饮食行为测量，同时还可以探索可能导致这种行为的新的遗传变异。 范围 本研究的目的是利用PEAS样本研究妊娠和产后饮食和体重变化背景下与味觉和食物奖励敏感性相关的遗传多态性。

BACKGROUND AND INTRODUCTION The purpose of the Pregnancy Eating Attributes Study (PEAS) is to examine the role of food reward sensitivity in maternal diet and weight change during pregnancy and postpartum. The study examines the interplay of food reward sensitivity with behavioral control, home food environment, and related aspects of eating behavior in the context of weight-related biomedical, psychosocial, genetic and behavioral factors including physical activity, stress, sleep and depression. Women of varying weight were enrolled early in pregnancy and followed, along with their infants, until 1 year postpartum. Assessments occurred during each trimester of pregnancy, and postpartum at approximately 2 months, 6 months, 9 months and 12 months. Maternal food reward sensitivity, self-control, home food environment, eating behaviors, dietary intake, health behaviors, and anthropometrics were assessed along with maternal and infant clinical and biological data, infant anthropometrics, and feeding practices. Primary exposures of interest included food reward sensitivity, behavioral control, and home food environment. Primary outcomes included gestational weight gain, postpartum weight retention and maternal diet quality. The past number of years has seen an increase in published research exploring neurological and genetic aspects of food reward sensitivity. Of interest are the numerous substantiated reports of polymorphisms that seem to contribute to variations in individual responses to hyperpalatable foods, for example. The PEAS study provides a unique opportunity to examine such questions in a large cohort with a wealth of related eating behavior measures, but also to explore new genetic variations that could contribute to such behavior. SCOPE This task order is to utilize the PEAS specimens to investigate the genetic polymorphisms related to taste and food reward sensitivity in the context of pregnancy and postpartum diet and weight change.