Electronic Cigarettes During Pregnancy: Impact on Fetal Development

怀孕期间电子烟：对胎儿发育的影响

• 批准号: 10415154
• 负责人: LAURA R STROUD
• 金额: $ 60.8万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415154
• 关键词: 3-Dimensional; 3D ultrasound; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; Address; Age; Animals; Area; Arousal; Attention; Behavioral; Biological; Biological Markers; Birth; Birth Weight; Brain; Carbon Monoxide; Cephalic; Cerebellum; Child; Child Health; Cigarette; Clinical; Cohort Studies; Corpus Callosum; Cost efficiency; Cotinine; Data; Development; Discipline of obstetrics; Drug usage; Electronic cigarette; Environment; Exposure to; Fetal Development; Fetal Growth; Fetal Neurobehavioral Development; Fetus; Gestational Age; Goals; Growth; Harm Reduction; Head circumference; Health protection; Human; Image; Infant; Informal Social Control; Investigation; Literature; Longevity; Measures; Methods; Mothers; National Institute of Drug Abuse; Neonatal; Nicotine; Outcome; Postpartum Period; Pregnancy; Pregnant Women; Provider; Public Health; Publishing; Relative Risks; Reporting; Reproductive Health; Research; Resolution; Risk; Risk Marker; Sampling; Seminal; Smoking; Strategic Planning; Structure; System; Time; Tobacco; Tobacco-Associated Carcinogen; Toxic effect; Ultrasonography; Vaporizer; Woman; biobehavior; biological adaptation to stress; biomarker development; carcinogenicity; cigarette smoking; cohort; combustible cigarette; combustion product; developmental toxicity; electronic cigarette use; electronic cigarette user; electronic liquid; fetal; frontal lobe; high risk infant; image processing; innovation; maternal cigarette smoking; neural; neurobehavior; neurobehavioral; novel; pregnant; prenatal; prenatal exposure; prospective; recruit; social; tobacco products; two-dimensional; ultrasound

Project Summary/Abstract While cigarette use has declined in the US, use of electronic cigarettes (e-cigs) has increased dramatically since their introduction to the US in 2007. Tremendous controversy has emerged regarding their potential risks (renormalizing smoking, dangers of e-liquids) versus potential for harm reduction (“clean” nicotine delivery sys- tem without tobacco combustion products). The question of risks vs harm reduction is even more salient during pregnancy due to impact of maternal use on both mother and fetus and evidence for vulnerabil- ity of the developing fetus to both nicotine and combustion products. Recent published reports reveal rates of e-cig use of 4-15% among pregnant women; pilot data from our group revealed doubling of prenatal e- cig use between 2012 and 2017. Given evidence of increasing e-cig use by pregnant women, known fetal tox- icity from nicotine, and a need for data to inform pregnant women and obstetric providers, research to deter- mine the impact and relative impact (vs cigarettes) of e-cigs on fetal development is urgently needed. To date, however, there are no published studies of the impact of e-cig use during pregnancy on fetal develop- ment. We propose the first study of the impact of e-cigs during pregnancy on the developing fetus, in- cluding markers of fetal growth and novel measures of fetal brain and neurobehavioral development. Our group pioneered combined use of real-time ultrasound and fetal actocardiography to characterize fetal neurobehavior. The advent of 3D ultrasound offers higher resolution fetal images and allows volumetric char- acterization of specific fetal brain structures. Seminal preliminary data from our group highlights feasibility of recruiting pregnant e-cig users as well as initial evidence for alterations in fetal growth, fetal fronto-cerebellar brain structures and fetal neurobehavioral development in e-cig users. The proposed study is an intensive pro- spective investigation of three groups of mother-fetus pairs: E-cig users, Cig users and Controls. Comprehen- sive measures of fetal growth, neural structures, and neurobehavioral development will be assessed over preg- nancy using 2D and 3D ultrasonography followed by neonatal ultrasound and neurobehavioral assessment. Maternal and fetal nicotine, combustion and carcinogenicity biomarkers will also be assessed. Our goals are to determine the impact of prenatal e-cigs on: (1) fetal growth and infant birth weight, (2) fetal/infant brain devel- opment, (3) fetal/infant neurobehavioral development. We will also explore: (4) associations between nicotine and toxicity biomarkers with fetal growth, brain and neurobehavioral development. The proposed study ad- dresses an urgent and unanswered public health question. Given increasing rates of e-cig use and the exquis- ite sensitivity of the developing fetus to disruptions in the prenatal environment, determining the risks and rela- tive risks of e-cig use in pregnancy is timely and offers potential to impact the health of reproductive age women and their children.

项目概要/摘要 虽然美国的香烟使用量有所下降，但电子烟的使用量却急剧增加 自 2007 年引入美国以来，其潜在风险引发了巨大争议 （重新正常化吸烟、电子液体的危险）与减少危害的潜力（“清洁”尼古丁输送系统） 不含烟草燃烧产物的 tem）。风险与减少伤害的问题更加突出 怀孕期间由于母亲使用对母亲和胎儿的影响以及易受伤害的证据 发育中的胎儿对尼古丁和燃烧产物的影响。最近发表的报告显示 孕妇电子烟使用率为 4-15%；我们小组的试点数据显示产前电子增加了一倍 2012 年至 2017 年间，电子烟的使用情况有所增加。鉴于孕妇使用电子烟的情况有所增加，已知的胎儿毒性 尼古丁的危害，需要数据来告知孕妇和产科提供者，进行研究以阻止 迫切需要了解电子烟对胎儿发育的影响和相对影响（与香烟相比）。 然而，迄今为止，尚未发表关于怀孕期间使用电子烟对胎儿发育影响的研究。 ment。我们提出第一项关于怀孕期间电子烟对发育中的胎儿的影响的研究， 包括胎儿生长标志物以及胎儿大脑和神经行为发育的新测量方法。 我们小组率先结合使用实时超声和胎儿心电图来表征胎儿 神经行为。 3D 超声的出现提供了更高分辨率的胎儿图像，并允许体积特征 特定胎儿大脑结构的特征化。我们小组的开创性初步数据强调了可行性 招募怀孕的电子烟使用者以及胎儿生长、胎儿额小脑改变的初步证据 电子烟使用者的大脑结构和胎儿神经行为发育。拟议的研究是一项深入的亲 对三组母婴对进行前瞻性调查：电子烟使用者、香烟使用者和对照组。理解- 胎儿生长、神经结构和神经行为发育的严重测量将在孕前进行评估 nancy 使用 2D 和 3D 超声检查，然后进行新生儿超声和神经行为评估。 还将评估母体和胎儿的尼古丁、燃烧和致癌性生物标志物。我们的目标是 确定产前电子烟对：（1）胎儿生长和婴儿出生体重，（2）胎儿/婴儿大脑发育的影响 （3）胎儿/婴儿神经行为发育。我们还将探讨：（4）尼古丁之间的关联 以及与胎儿生长、大脑和神经行为发育有关的毒性生物标志物。拟议的研究广告 解决了一个紧迫且尚未解答的公共卫生问题。鉴于电子烟使用率的不断增加和精致的 发育中的胎儿对产前环境破坏的敏感性，确定风险和相关性 怀孕期间使用电子烟的风险是及时的，并且有可能影响育龄期的健康 妇女和她们的孩子。

项目成果

Flavored waterpipe tobacco preferences, perceptions, and use in pregnant women: A latent factor mapping approach.

• DOI: 10.1016/j.addbeh.2021.107194
• 发表时间: 2022-03
• 期刊: Addictive behaviors
• 影响因子: 4.4
• 作者: Stroud LR;Papandonatos GD;Sharma E;Jao NC;Goldman S;Vergara-Lopez C;Scott-Sheldon LAJ
• 通讯作者: Scott-Sheldon LAJ

Variations in Electronic Nicotine Delivery System (ENDS) device types and association with cigarette quit attempts.

• DOI: 10.1016/j.ypmed.2021.106588
• 发表时间: 2021-07
• 期刊: Preventive medicine
• 影响因子: 5.1
• 作者: Sharma E;Yang DH;Stroud LR
• 通讯作者: Stroud LR

Maternal smoking in pregnancy, fetal activity & newborn behavioral state: An observational ultrasound study.

母亲怀孕期间吸烟与胎儿活动

• DOI: 10.1016/j.ntt.2020.106894
• 发表时间: 2020
• 期刊: Neurotoxicology and teratology
• 影响因子: 2.9
• 作者: Stroud,LauraR;Bublitz,MargaretH;Crespo,FrankA;Lester,Barry;Salisbury,AmyL
• 通讯作者: Salisbury,AmyL