Tissue microenvironment (TIMe) training program

项目概要/摘要 对组织微环境 (TiMe) 的定量理解对于推进生物医学至关重要 知识和医疗保健，从再生医学到管理癌症负担。训练 生产力的科学领导者，三个技术领域的教育至关重要：(a) 传感和成像 测量生化和生物物理特性，(b) 生物工程以概括 TiMe，以及 (c) 计算建模和分析以获得洞察力。因此，我们建议继续进行TiMe培训 博士前学生将三种技术方法与 TiMe 相关的生物技术相结合的项目 疾病和发展的背景，以开展成功的研究生涯。培训内容包括四大核心 组成部分——确保技术深度和批判性思维以及适当广度的课程活动 学科、课外活动以培养实用技能、专业发展以增强学员能力 成为研究领导者，职业发展使受训者能够做出终身贡献 社会。这些活动旨在简化教育并有效地关注获奖者的研究 博士学位包括一个特殊的称号（集中在TiMe）。过去的项目期是我们的第一个项目期 在制定该计划、其活动和进一步完善该计划的评估方面取得了进展。建立在 受训者的成功（所有 10 名毕业生都从事生物医学研究职业，每位受训者约 5.5 篇论文，以及 大量的后续资金和奖项），我们建议继续学生发展活动，添加一部小说 基于新建实验室的实践教育部分，强调新兴科学 主题包括机器学习和设计思维。伊利诺伊州有非常严格的纪律计划， 涵盖该项目的多元化教师、适当的设施和每个技术领域的独特资源 地区。 TiMe 培训计划的显着优势在于我们拥有成功的研究生培训历史， 包括对多样性和残疾人的承诺、富有成效的合作文化、新的 生物工程系以及强大的机构支持（匹配的直接支持 - 150 万美元和 290 万美元） 全面支持）。四十名教师将担任教师导师，另外四名教师将在教学法、评估方面具有专业知识 和专业发展，为该计划提供关键资源。我们建议至少教育十二人 受训人员（六名来自 NIH 支持，六名匹配名额来自机构支持）每人最多两年。六 每年都会从校园内强大的申请人库中任命实习生。传统教育将进一步 通过共同指导的研究得到加强，并通过新的工程获得转化机会的可能性 为基础的医学院。整个计划的结果将得到严格评估，以改进培训， 指导行政决策并传播最佳实践。愿景、专业知识和 伊利诺伊州 TimeMe 培训计划的基础设施将确保从强大而多样化的学员中选出 研究生社区将提供持续的研究贡献，以造福公众健康。

Project Summary/Abstract A quantitative understanding of the tissue microenvironment (TiMe) is critical for advancing biomedical knowledge and healthcare, ranging from regenerative medicine to managing the burden of cancer. To train productive scientific leaders, education in three technological areas is essential: (a) sensing and imaging to measure biochemical and biophysical properties, (b) bioengineering to recapitulate the TiMe, and (c) computational modeling and analytics to gain insight. Accordingly, we propose to continue the TiMe training program wherein predoctoral students integrate the three technological approaches with TiMe-related biological contexts of disease and development to launch successful research careers. Training includes four core components—Curricular Activities to ensure technical depth and critical thinking with apposite breadth across disciplines, Extracurricular Activities to develop pragmatic skills, Professional Development to empower trainees to become research leaders, and Career Development to position trainees to make lifelong contributions to society. The activities are structured to streamline education and efficient focus on research with the awarded doctoral degree to include a special designation (concentration in TiMe). This past project period was our first and progress was made in establishing the program, its activities and evaluation to refine it further. Building upon the success of trainees (all ten graduated are in biomedical research careers, ~5.5. papers per trainee, and significant follow-on funding and awards), we propose to continue student development activities, add a novel hands-on education component based on a newly constructed laboratory and emphasize emerging scientific topics including machine learning and design thinking. Illinois has exceptionally strong disciplinary programs, diverse faculty spanning the program, appropriate facilities and unique resources in each of these technological areas. The TiMe Training Program is distinctly advantaged by our strong history of successful graduate training, including a commitment to diversity and individuals with disabilities, a culture of productive collaboration, a new Department of Bioengineering, and strong institutional support (matching direct support - $1.5 M and $2.9 M of total support). Forty faculty will serve as faculty mentors and another four, with expertise in pedagogy, evaluation and professional development, provide critical resources for the program. We propose to educate at least twelve trainees (six from NIH support and six matching slots from Institutional support) for up to two years each. Six trainees will be appointed annually from a strong applicant pool across campus. Traditional education will further be enhanced by co-mentored research with possibilities of translational opportunities via a new engineering- based College of Medicine. Outcomes will be rigorously evaluated throughout the program to improve training, to guide administrative decision-making and to disseminate best practices. The vision, expertise, and infrastructure of the Illinois TiMe Training Program will ensure that trainees selected from a strong and diverse graduate community will provide sustained research contributions to benefit public health.