Tissue microenvironment (TIMe) training program

项目总结/摘要 定量了解组织微环境（TiMe）对于推进生物医学的发展至关重要。 知识和医疗保健，从再生医学到管理癌症负担。培养 生产力的科学领导人，在三个技术领域的教育是必不可少的：（a）传感和成像， 测量生物化学和生物物理性质，（B）生物工程以概括时间序列，和（c） 计算建模和分析，以获得洞察力。因此，我们建议继续进行时间管理培训， 一个程序，其中博士前的学生整合三种技术方法与时间相关的生物 疾病和发展的背景下启动成功的研究事业。培训包括四个核心 课程活动，以确保技术深度和批判性思维与适当的广度跨越 学科，课外活动，以发展务实的技能，专业发展，以赋予学员 成为研究领导者，职业发展定位学员，使其终身贡献， 社会这些活动的结构是为了简化教育和有效的重点研究与获奖 博士学位，包括一个特殊的名称（浓度在时间）。过去的这个项目时期是我们第一次 在制定方案、开展活动和进行评估以进一步完善方案方面取得了进展。基础上 受训人员的成功（所有十名毕业生都从事生物医学研究工作，约5.5。每名学员的论文，以及 重要的后续资金和奖项），我们建议继续学生发展活动，增加一个新的 在新建实验室的基础上进行实践教育，强调新兴科学 主题包括机器学习和设计思维。伊利诺斯州有非常强的纪律项目， 跨程序，适当的设施和独特的资源，在这些技术的每一个不同的教师 地区该时间培训计划是明显由我们成功的研究生培训的强大历史， 包括对多样性和残疾人的承诺，富有成效的合作文化，新的 生物工程系，以及强大的机构支持（匹配直接支持-150万美元和290万美元， 全面支持）。40名教师将担任教师导师，另外4名教师将担任教育学，评估和评估方面的专业知识 和专业发展，为该计划提供关键资源。我们建议至少教育12个 培训生（6名来自国家卫生研究院的支持，6名来自机构支持的匹配名额），每人最多两年。六 学员将每年从校园内大量的申请者中任命。传统教育将进一步 通过共同指导的研究得到加强，通过新的工程技术提供翻译机会的可能性- 医学院的基础。在整个项目中将严格评估结果，以改善培训， 指导行政决策并传播最佳做法。我们的愿景、专业知识和 伊利诺伊州时间培训计划的基础设施将确保学员从一个强大的和多样化的选择， 研究生社区将提供持续的研究贡献，以造福公共卫生。

Project Summary/Abstract A quantitative understanding of the tissue microenvironment (TiMe) is critical for advancing biomedical knowledge and healthcare, ranging from regenerative medicine to managing the burden of cancer. To train productive scientific leaders, education in three technological areas is essential: (a) sensing and imaging to measure biochemical and biophysical properties, (b) bioengineering to recapitulate the TiMe, and (c) computational modeling and analytics to gain insight. Accordingly, we propose to continue the TiMe training program wherein predoctoral students integrate the three technological approaches with TiMe-related biological contexts of disease and development to launch successful research careers. Training includes four core components—Curricular Activities to ensure technical depth and critical thinking with apposite breadth across disciplines, Extracurricular Activities to develop pragmatic skills, Professional Development to empower trainees to become research leaders, and Career Development to position trainees to make lifelong contributions to society. The activities are structured to streamline education and efficient focus on research with the awarded doctoral degree to include a special designation (concentration in TiMe). This past project period was our first and progress was made in establishing the program, its activities and evaluation to refine it further. Building upon the success of trainees (all ten graduated are in biomedical research careers, ~5.5. papers per trainee, and significant follow-on funding and awards), we propose to continue student development activities, add a novel hands-on education component based on a newly constructed laboratory and emphasize emerging scientific topics including machine learning and design thinking. Illinois has exceptionally strong disciplinary programs, diverse faculty spanning the program, appropriate facilities and unique resources in each of these technological areas. The TiMe Training Program is distinctly advantaged by our strong history of successful graduate training, including a commitment to diversity and individuals with disabilities, a culture of productive collaboration, a new Department of Bioengineering, and strong institutional support (matching direct support - $1.5 M and $2.9 M of total support). Forty faculty will serve as faculty mentors and another four, with expertise in pedagogy, evaluation and professional development, provide critical resources for the program. We propose to educate at least twelve trainees (six from NIH support and six matching slots from Institutional support) for up to two years each. Six trainees will be appointed annually from a strong applicant pool across campus. Traditional education will further be enhanced by co-mentored research with possibilities of translational opportunities via a new engineering- based College of Medicine. Outcomes will be rigorously evaluated throughout the program to improve training, to guide administrative decision-making and to disseminate best practices. The vision, expertise, and infrastructure of the Illinois TiMe Training Program will ensure that trainees selected from a strong and diverse graduate community will provide sustained research contributions to benefit public health.