Tissue microenvironment (TIMe) training program

项目摘要/摘要 对组织微环境(时间)的定量了解是推进生物医学的关键 知识和医疗保健，从再生医学到管理癌症负担。训练 作为富有成效的科学领袖，在三个技术领域的教育是必不可少的：(A)传感和成像 测量生化和生物物理特性，(B)生物工程，以概括时间，和(C) 计算建模和分析以获得洞察力。因此，我们建议继续进行时间培训 博士前学生将三种技术方法与与时间相关的生物学相结合的项目 在疾病和发展的背景下开展成功的研究事业。培训包括四个核心 组成部分-确保技术深度和批判性思维的课程活动具有适当的广度 学科，课外活动培养实用技能，专业发展赋予学员权力 成为研究带头人，职业发展定位学员终身贡献 社会。这些活动的结构是为了简化教育并有效地专注于研究，并与获奖的 博士学位包括特殊称谓(集中在时间上)。过去的这个项目期是我们的第一个 在制定该方案、开展活动和进行评估以进一步完善该方案方面取得了进展。建立在 学员的成功(10名毕业生均在生物医学研究领域，约5.5%)。每位实习生的论文，以及 重大后续资金和奖项)，我们建议继续开展学生发展活动，增加一个新颖的 以新建实验室为基础的实践教学部分，强调新兴科学 主题包括机器学习和设计思维。伊利诺伊州有非常强大的纪律程序， 该项目拥有多元化的师资队伍、适当的设施和独特的技术资源 区域。时间培训计划明显得益于我们成功的研究生培训历史， 包括对多样性和残疾人的承诺，富有成效的合作文化，新的 生物工程系和强有力的机构支持(匹配的直接支持-150万美元和290万美元 完全支持)。40名教员将担任教员导师，另外4名具有教育学、评估方面的专业知识。 和专业发展，为项目提供关键资源。我们建议教育至少十二个人 受训人员(六名来自NIH支持部门，六名来自机构支持部门)，每人最多两年。六 实习生将每年从校园内强大的申请者库中被任命。传统教育将进一步 通过联合指导的研究和通过新工程提供翻译机会的可能性来增强- 以医学院为基地。在整个项目中，将严格评估结果，以改进培训， 指导行政决策和传播最佳做法。愿景、专业知识和 伊利诺伊州时间培训计划的基础设施将确保学员从强大和多样化的 研究生社区将为造福公众健康提供持续的研究贡献。

Project Summary/Abstract A quantitative understanding of the tissue microenvironment (TiMe) is critical for advancing biomedical knowledge and healthcare, ranging from regenerative medicine to managing the burden of cancer. To train productive scientific leaders, education in three technological areas is essential: (a) sensing and imaging to measure biochemical and biophysical properties, (b) bioengineering to recapitulate the TiMe, and (c) computational modeling and analytics to gain insight. Accordingly, we propose to continue the TiMe training program wherein predoctoral students integrate the three technological approaches with TiMe-related biological contexts of disease and development to launch successful research careers. Training includes four core components—Curricular Activities to ensure technical depth and critical thinking with apposite breadth across disciplines, Extracurricular Activities to develop pragmatic skills, Professional Development to empower trainees to become research leaders, and Career Development to position trainees to make lifelong contributions to society. The activities are structured to streamline education and efficient focus on research with the awarded doctoral degree to include a special designation (concentration in TiMe). This past project period was our first and progress was made in establishing the program, its activities and evaluation to refine it further. Building upon the success of trainees (all ten graduated are in biomedical research careers, ~5.5. papers per trainee, and significant follow-on funding and awards), we propose to continue student development activities, add a novel hands-on education component based on a newly constructed laboratory and emphasize emerging scientific topics including machine learning and design thinking. Illinois has exceptionally strong disciplinary programs, diverse faculty spanning the program, appropriate facilities and unique resources in each of these technological areas. The TiMe Training Program is distinctly advantaged by our strong history of successful graduate training, including a commitment to diversity and individuals with disabilities, a culture of productive collaboration, a new Department of Bioengineering, and strong institutional support (matching direct support - $1.5 M and $2.9 M of total support). Forty faculty will serve as faculty mentors and another four, with expertise in pedagogy, evaluation and professional development, provide critical resources for the program. We propose to educate at least twelve trainees (six from NIH support and six matching slots from Institutional support) for up to two years each. Six trainees will be appointed annually from a strong applicant pool across campus. Traditional education will further be enhanced by co-mentored research with possibilities of translational opportunities via a new engineering- based College of Medicine. Outcomes will be rigorously evaluated throughout the program to improve training, to guide administrative decision-making and to disseminate best practices. The vision, expertise, and infrastructure of the Illinois TiMe Training Program will ensure that trainees selected from a strong and diverse graduate community will provide sustained research contributions to benefit public health.