EVALUATION OF MINERAL ABSORPTION IN INFANTS FED INFANT FORMULA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 摘要 我们建议使用稳定同位素方法来评估婴儿对钙的吸收。来自市场上的婴儿配方奶粉和含有益生素的配方奶粉中的钙将被评估。这些研究将在选择与大休斯顿地区种族分布相匹配的男女婴儿中进行。钙的吸收将使用多示踪稳定同位素方法进行测量，并通过尿液回收给药的同位素。这项研究的结果将提供有关益生元对婴儿钙吸收的影响的信息。数据将与之前对母乳喂养的婴儿的研究进行比较。 假设 含有益生素的婴儿配方奶粉吸收的总钙显著高于市售配方奶粉。这两组婴儿的吸收将与之前研究的母乳喂养婴儿组相同或更大。 具体目标 这项研究的主要目的是评估健康的足月儿吸收的钙量，无论是市场上销售的牛奶，全乳糖婴儿配方奶粉和益生菌混合物，并确定两种婴儿配方奶粉之间的钙吸收毫克/100千卡的差异。 本研究的次要目标是比较两组患者的血浆25-羟基维生素D水平、血钙和24小时尿钙水平。 另一个次要目标是根据之前使用基本上相同的方案收集的数据，比较这两种配方奶粉对钙的吸收与从母乳中吸收钙的情况。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ABSTRACT We propose to evaluate calcuim absorption in infants using stable isotope methods. Calcium from a marketed infant formula and a formula containing prebiotics will be evaluated. These studies will be performed in infants of both genders who are selected to match the ethnic distribution of the greater Houston area. Absorption of calcium will be measured using multi-tracer stable isotope methods with urinary recovery of the administered isotopes. The findings from this study will provide information on the effect of prebiotics on calcium absorption in infants. Data will be compared with previous studies of human milk-fed infants. HYPOTHESIS Total calcium absorbed witll be significantly greater in the prebiotic containing infant formula than the marketed formula. Absorption from both groups will be equal or greater than that from previously studied group of human milk-fed infants. SPECIFIC AIMS The primary objective of this study is to evaluate the amount of calcium abosrbed in healthy, term infants fed either marketed cow's-milk, full lactose containing infant formula with a prebiotic blend and to determine differences in mg/100kcal of calcium absorption between two infant formulas. The secondary objective of this study are to compare the levels of plasma 25-hydroxyvitamin D, serum calcium, and 24-hour urine calcium levels between the two groups. An additional secondary objective is to compare the absorption of calcium from both formulas with calcium absorption from human milk based on data previously collected using an essentially identical protocol.