HUMAN TISSUE ACQUISITION & PATHOLOGY SHARED RESOURCES

人体组织采集

• 批准号: 7679668
• 负责人: MARY Kay WASHINGTON
• 金额: $ 38.63万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7679668
• 关键词: Address; Area; Autopsy; Basic Science; Biochemical; Biochemistry; Biohazardous Substance; Bioinformatics; Bioinformatics Shared Resource; Biological Preservation; Biopsy; Breast; Budgets; Cancer Center; Cancer Center Support Grant; Chemoprevention; Climate; Clinical; Clinical Trials; Clinical Trials, Other; Collection; Colorectal Cancer; Communities; Computer software; Confidentiality of Patient Information; Consent Forms; Cooperative Human Tissue Network; Custom; Data; Digestive System Disorders; Disease; Ensure; Equipment; Evaluation; Excision; Exposure to; Facility Construction Funding Category; Fostering; Foundations; Freezing; Funding; Genomics; Guidelines; Health Services Accessibility; Histology; Hospitals; Housing; Human; Image; Improve Access; Informatics; Informed Consent; Investigation; Laboratories; Lasers; Malignant Neoplasms; Medical Records; Methods; Microscopy; Mission; Molecular; Necrosis; Neoplasms; Numbers; Operative Surgical Procedures; Pathology; Patients; Peer Review; Play; Process; Program Research Project Grants; Proteomics; Protocols documentation; Purpose; Quality Control; Range; Recruitment Activity; Reproduction spores; Research; Research Ethics Committees; Research Personnel; Resource Sharing; Resources; Role; Sampling; Services; Site; Source; Specimen; Standards of Weights and Measures; Supercomputing; System; The Vanderbilt-Ingram Cancer Center at the Vanderbilt University; Tissue Banks; Tissue Microarray; Tissue Sample; Tissues; Translational Research; Universities; Washington; Work; experience; gastrointestinal; human subject; human tissue; interest; member; neoplastic; prospective; repository; research study; restraint; sample collection; tissue fixing; tool

The purpose of the VICC Human Tissue Acquisition and Pathology Shared Resource (HTAP) is to provide support for Cancer Center investigators engaged in translational and basic science research efforts. It provides researchers with access to a wide variety of human specimens and tissues. The objectives of HTAP are to collect, process, bank, and distribute remnant human tissues (both normal and neoplastic) from routine surgical resections and autopsies for use by peer-reviewed funded investigators of the VICC in basic, clinical, and translational research studies; provide the highest quality of well-characterized fresh, frozen, and fixed tissues suitable for a wide range of molecular, biochemical, and tissue analyses; assist with collection and banking of biopsy material for specific cancer-related clinical trials and other projects; provide, as feasible, human tissues to other peer-reviewed funded Vanderbilt University investigators who are not members of the VICC, and to newly-established investigators who have yet to receive funding; and to perform quality control to ensure that the relevant tissue is supplied to the researcher, and that tissues are suitable for the planned research (e.g., not necrotic or involved by unsuspected disease processes.) New services offered by HTAP include laser capture microscopy, tissue array block construction, and access to the BLISS automated software/imaging system. In addition, tissue collection efforts have been extensively refined and new preservation methods offered. Dr. Kay Washington is the Director of the Human Tissue Acquisition and Pathology Shared Resource and is engaged in a number of collaborative projects with VICC investigators. She is assisted by a staff with decades of experience in offering these services, and partners with the Bioinformatics Shared Resource, under the direction of Dr. Mary Edgerton, to develop easily-customized tools for specimen tracking and linkage of genomic, proteomic and biologic data to tissue specimens.

VICC 人体组织采集和病理学共享资源 (HTAP) 的目的是为从事转化和基础科学研究工作的癌症中心研究人员提供支持。它为研究人员提供了获取各种人体标本和组织的机会。 HTAP 的目标是收集、处理、储存和分发常规手术切除和尸检中剩余的人体组织（正常组织和肿瘤组织），供经同行评审资助的 VICC 研究人员用于基础、临床和转化研究；提供最高质量的、表征良好的新鲜、冷冻和固定组织，适用于广泛的分子、生化和组织分析；协助收集和储存特定癌症相关临床试验和其他项目的活检材料；在可行的情况下，向其他非 VICC 成员的同行评审资助的范德比尔特大学研究人员以及尚未获得资助的新成立的研究人员提供人体组织； HTAP 提供的新服务包括激光捕获显微镜、组织阵列块构建以及 BLISS 自动化软件/成像系统的访问。此外，组织收集工作也已广泛开展 提供了精致和新的保存方法。 Kay Washington 博士是人体组织采集和病理学共享资源的主管，并与 VICC 研究人员一起参与了许多合作项目。她在提供这些服务方面拥有数十年经验的工作人员的协助下，并在 Mary Edgerton 博士的指导下与生物信息学共享资源合作，开发用于样本跟踪和分析的易于定制的工具。 将基因组、蛋白质组和生物学数据与组织样本联系起来。