HIGH MASS-TO-CHARGE FOURIER TRANSFORM MASS SPECTROMETRY

高质荷傅里叶变换质谱

• 批准号: 8361323
• 负责人: MICHAEL L GROSS
• 金额: $ 1.26万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361323
• 关键词: Cells; Charge; Detection; Effectiveness; Fourier Transform; Funding; Goals; Grant; Ions; Mass Spectrum Analysis; Motion; National Center for Research Resources; Peptides; Principal Investigator; Proteins; Proteomics; Research; Research Infrastructure; Research Project Grants; Resources; Source; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Testing; United States National Institutes of Health; biomedical resource; cost; electrical property; improved; instrumentation; interest; magnetic field

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purposes of the research are to understand ion motion in modified FTMS traps, to construct traps guided by the theoretical considerations, and to test the effectiveness of the electrically compensated cell to study high-mass ions generated by MALDI. The goal of this core research project is to improve the detection for biomolecule ions with mass-to-charge ratios greater than a few thousand by making changes to the electrical properties of the trap rather than by increasing the magnetic field strength. We suggest that the instrumentation will not only be of interest for mid-sized proteins but also for peptides in proteomics applications.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 研究的目的是了解改进的FTMS陷阱中的离子运动，在理论考虑的指导下构建陷阱，并测试电子补偿室研究MALDI产生的高质量离子的有效性。这一核心研究项目的目标是通过改变陷阱的电学性质而不是通过增加磁场强度来提高对质量电荷比大于几千的生物分子离子的检测。我们认为，该仪器不仅对中等大小的蛋白质感兴趣，而且对蛋白质组学应用中的多肽也有兴趣。