Predoctoral Training at the Chemistry-Biology Interface

化学-生物学界面的博士前培训

• 批准号: 10024683
• 负责人: Ronen Marmorstein
• 金额: $ 28.92万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10024683
• 关键词: Biology; Chemistry; Training; pre-doctoral

The goal of the CBI Training Program is to provide students with the intellectual and technical skills that are necessary to solve important and complex biological problems that can be most effectively addressed by studies at the chemistry-biology interface. We are focusing on the mechanistic chemistry of biomolecules that have implications for impacting human health and treatment of disease. This is a theme that is of interest to a significant population of students on campus and serves as an excellent system for the application of tools at the chemistry-biology interface to solve important biological problems. The program creates a group of chemists and biologists who can speak the same language and thereby function effectively in multidisciplinary teams. The Program involves 34 participating faculty from two separate Schools within the University of Pennsylvania, The Perelman School of Medicine (SOM) and The School of Arts and Sciences (SAS). Participating students come primarily from two graduate groups that span institution and school boundaries, the Graduate Group in Chemistry (CHEM, in SAS) and the Graduate Group in Biochemistry and Molecular Biophysics (BMB, in SOM). To ensure that students carry out research within the scope of the training program, students are selected for the program after they have chosen a thesis laboratory and project and generally in their second year. To ensure chemistry-biology interface training and cross-fertilization between the chemistry and biology students that participate in the program, students participate in the following activities: (1) research at the chemistry-biology interface, (2) didactic course-work dealing with the chemistry and biology of proteins, nucleic acids and small biomolecules, including a literature-based component, (3) an annual student-run Chemical Biophysics mini-symposia series, (4) twice monthly student luncheons, (5) an annual Chemistry-Biology Interface retreat, (6) an annual mid-Atlantic Frontiers at the Chemistry-Biology Interface Symposium, and (7) a structured career development plan. The program also has effective mechanisms in place for the recruitment and retention of underrepresented minorities as well as the disadvantaged and disabled, and for student instruction in the responsible conduct of research. We request funds for a steady state predoctoral training group of ~ 40 students, including 8 who are funded during years 2 and 3. Oversite of the Training Program is by the PI, Ronen Marmorstein and Co-PI, E. James Petersson, with input from CHEM (SAS) and BMB (SOM) External Advisory Committees and Internal CBI Training Committee, comprised of roughly equal faculty representation from the two participating schools and trainee representatives, which meets every 6 months. The CBI Training Committee votes on the selection of students for funded training slot positions, ensuring equitable distribution of students, encouraging applications from underrepresented minorities, the disadvantaged and disabled and administering other functions of the program.

CBI培训计划的目标是为学生提供知识和技术技能， 解决重要而复杂的生物学问题是必要的，这些问题可以最有效地解决， 化学-生物学界面的研究。我们专注于生物分子的机械化学， 对影响人类健康和治疗疾病具有重要意义。这是一个令人感兴趣的主题， 学生在校园里的显着人口，并作为一个很好的系统的工具应用在 化学-生物学接口，以解决重要的生物学问题。该程序创建了一组 化学家和生物学家谁可以说同一种语言，从而有效地发挥作用，在多学科 团队该计划涉及34名参与教师从两个不同的学校在大学内 宾夕法尼亚州，佩雷尔曼医学院（SOM）和艺术与科学学院（SAS）。 参与的学生主要来自两个跨越机构和学校界限的研究生群体， 化学研究生组（化学，在SAS）和生物化学和分子研究生组 生物物理学（BMB，在SOM）。确保学生在培训范围内开展研究 程序，学生被选中的程序后，他们选择了论文实验室和项目， 一般在第二年。确保化学-生物学接口培训和 参加该计划的化学和生物学学生，学生参加以下活动 活动：（1）化学-生物学界面研究，（2）化学教学课程 和蛋白质、核酸和小生物分子的生物学，包括基于文献的部分，（3） 每年一次的学生化学生物物理小型研讨会系列，（4）每月两次的学生午餐会，（5） 每年一度的化学-生物学接口务虚会，（6）每年一度的大西洋中部前沿化学-生物学 界面研讨会;（7）结构化的职业发展计划。该方案还具有有效的 为征聘和留住代表性不足的少数群体而建立的机制，以及 为弱势群体和残疾人，并为学生在负责任的研究行为的指导。我们要求 为约40名学生的稳定状态博士前培训组提供资金，其中8人在第2年获得资助 和3.培训计划由PI Ronen Marmorstein和Co-PI E.詹姆斯·彼得森， CHEM（SAS）和BMB（SOM）外部咨询委员会和内部CBI培训委员会的投入， 由来自两所参与学校的大致相等的教师代表和实习生组成 代表，每6个月举行一次会议。CBI培训委员会对学生的选择进行投票 对于资助的培训名额职位，确保学生的公平分配，鼓励来自 代表性不足的少数群体、处境不利和残疾人的权利，以及管理 程序.