Predoctoral Training at the Chemistry-Biology Interface

这一博士前培训计划的目标是为学生提供智力和技术技能 需要解决重要而复杂的生物问题，而这些问题可以通过在 化学-生物接口，并培养一批能够有效地毕业的化学家和生物学家 在多学科团队中成功沟通和运作。培训计划的重点将是 蛋白质的机械化学，这是一个对相当多的教职员工和 为在校学生提供了一个优秀的模型系统，为化学工具的应用提供了重要的解决方案 生物问题。该计划将涉及来自维斯塔尔研究所的27名参与教职员工和两名独立的 宾夕法尼亚大学、医学院和文理学院内的学校。 参与的学生将主要来自两个跨越院校和学校界限的研究生群体， 化学研究生组和生物化学和生物物理学研究生组。确保学生随身携带 在培训计划范围内的研究，学生将在他们选择了 论文、实验室和项目，一般在二年级或三年级。以确保它们之间的异花授精 化学及生物专业的学生，如获培训资助，亦会参与下列活动： 活动：(1)跨越化学-生物学科界限的课程课程 蛋白质的机械化学，(2)学生举办的演讲邀请的研讨会和专题讨论会系列，围绕 化学-生物界面，(3)一年一度的化学-生物界面研讨会，学生在其中互动和 正式地向彼此和其他受训者介绍他们的工作，以及(4)学生和教职员工每月举行的午餐会 在他们之间非正式地讨论他们的研究。该方案还将通过招聘以下人员的计划 代表不足的少数群体和学生在负责任的研究行为方面的指导。我们申请资金用于一项 稳态博士前训练组，每组6名学生，每组支持3-4年。将成立一个培训委员会 由来自三个参与计划的大致相等的代表组成，将每月举行会议。培训 委员会将负责挑选学生参加培训，确保学生的公平分配， 鼓励代表人数不足的少数群体提出申请，并管理赠款的其他职能。

The goal of this predoctoral training program is to provide students with the intellectualand technical skills required to solve important and complex biological problems that can be most effectively addressed by studies at the chemistry-biology interface, and to create a group of graduating chemists and biologists who can effectively communicate and function successfully in multidisciplinaryteams. The focus of the training program will be mechanistic chemistry of proteins, which is a theme that is of special interest to a significant population of faculty and students on campus, and provides an excellent model system for the application of chemical tools to solve important biological problems. The Program will involve 27 participatingfaculty from The Wistar Institute and two separate Schools within the University of Pennsylvania, The School of Medicine and The School of Arts and Sciences. Participating students will come primarily from two graduate groups that span institutionand school boundaries, the Graduate Group in Chemistry and the Graduate Group in Biochemistry and Biophysics. To insure that students carry out research within the scope of the training program, students will be selected for the program after they have chosen a thesis laboratory and project and generally within their second or third year. To insure cross-fertilization between the chemistry and biology students, those selected for support by the training grant will also participate in the following activities: (1) A course curriculum that crosses the chemistry-biology academic boundary and centers around the mechanistic chemistry of proteins, (2) A student run speaker-invited seminar and symposia series centered around the chemistry-biology interface, (3) An annual Chemistry-Biology Interface Symposia in which students interact and formally present their work to each other and other trainees, and (4) A monthly luncheon in which students and faculty informally discuss their research among themselves. The program will also adopt plans for the recruitment of underrepresented minorities and for student instruction in the responsible conduct of research. We request funds for a steady state predoctoral training group of 6 students with 3-4 years of support each. A training committee will be comprised of roughly equal representation from the three participating programs and will meet monthly. The training committee will be responsible for selecting students for training slot positions, insure equitable distributionof students, encourage application from underrepresented minorities and administer other functions of the grant.