Predoctoral Training at the Chemistry-Biology Interface

CBI培训计划的目标是为学生提供以下智力和技术技能 解决重要而复杂的生物问题所必需的，这些问题可以通过以下方式最有效地解决 在化学-生物交界处学习。我们关注的是生物分子的机械化学 对影响人类健康和疾病治疗有影响。这是一个对 校园内的学生人数众多，是在以下方面应用工具的优秀系统 解决重要生物问题的化学-生物界面。该程序创建了一组 能说同一种语言，从而在多学科中有效发挥作用的化学家和生物学家 团队。该计划涉及34名参与该计划的教师，他们来自加州大学内两个不同的学院 宾夕法尼亚州佩雷尔曼医学院(SOM)和艺术与科学学院(SAS)。 参与的学生主要来自跨越院校和学校边界的两个研究生群体， 化学研究生组和生物化学与分子研究生组 生物物理学(BMB，SOM)。确保学生在培训范围内开展研究 计划，学生在选择了论文实验室和项目后被选入该计划 一般在他们的第二年。确保化学-生物接口训练和相互受精 参加该计划的化学和生物学生，学生参加以下活动 活动：(1)化学-生物界面的研究，(2)教学课程-处理化学的工作 和蛋白质、核酸和小生物分子的生物学，包括基于文献的成分，(3)和 每年由学生举办的化学生物物理小型研讨会系列，(4)每月两次的学生午餐会，(5)和 一年一度的化学-生物界面务虚会，(6)一年一度的化学-生物学中大西洋前沿 接口研讨会，以及(7)有条理的职业发展计划。该方案也有效地 为招募和保留任职人数偏低的少数群体以及 对于弱势群体和残疾人，以及在负责任的研究行为方面对学生进行指导。我们请求 为大约40名学生组成的稳定状态博士前培训小组提供资金，其中8名学生是在第二年获得资助的 和3.培训计划的网站由PI、Ronen Marmorstein和联合PI E.James Petersson与 来自CHEM(SAS)和BMB(SOM)外部咨询委员会和内部CBI培训委员会的意见， 由两所参与学校和实习生的大致相等的教职员工代表组成 代表，每6个月举行一次会议。CBI培训委员会对学生的选择进行投票 对于资助的培训时段职位，确保公平分配学生，鼓励来自 代表不足的少数群体、弱势群体和残疾人以及管理 程序。

The goal of the CBI Training Program is to provide students with the intellectual and technical skills that are necessary to solve important and complex biological problems that can be most effectively addressed by studies at the chemistry-biology interface. We are focusing on the mechanistic chemistry of biomolecules that have implications for impacting human health and treatment of disease. This is a theme that is of interest to a significant population of students on campus and serves as an excellent system for the application of tools at the chemistry-biology interface to solve important biological problems. The program creates a group of chemists and biologists who can speak the same language and thereby function effectively in multidisciplinary teams. The Program involves 34 participating faculty from two separate Schools within the University of Pennsylvania, The Perelman School of Medicine (SOM) and The School of Arts and Sciences (SAS). Participating students come primarily from two graduate groups that span institution and school boundaries, the Graduate Group in Chemistry (CHEM, in SAS) and the Graduate Group in Biochemistry and Molecular Biophysics (BMB, in SOM). To ensure that students carry out research within the scope of the training program, students are selected for the program after they have chosen a thesis laboratory and project and generally in their second year. To ensure chemistry-biology interface training and cross-fertilization between the chemistry and biology students that participate in the program, students participate in the following activities: (1) research at the chemistry-biology interface, (2) didactic course-work dealing with the chemistry and biology of proteins, nucleic acids and small biomolecules, including a literature-based component, (3) an annual student-run Chemical Biophysics mini-symposia series, (4) twice monthly student luncheons, (5) an annual Chemistry-Biology Interface retreat, (6) an annual mid-Atlantic Frontiers at the Chemistry-Biology Interface Symposium, and (7) a structured career development plan. The program also has effective mechanisms in place for the recruitment and retention of underrepresented minorities as well as the disadvantaged and disabled, and for student instruction in the responsible conduct of research. We request funds for a steady state predoctoral training group of ~ 40 students, including 8 who are funded during years 2 and 3. Oversite of the Training Program is by the PI, Ronen Marmorstein and Co-PI, E. James Petersson, with input from CHEM (SAS) and BMB (SOM) External Advisory Committees and Internal CBI Training Committee, comprised of roughly equal faculty representation from the two participating schools and trainee representatives, which meets every 6 months. The CBI Training Committee votes on the selection of students for funded training slot positions, ensuring equitable distribution of students, encouraging applications from underrepresented minorities, the disadvantaged and disabled and administering other functions of the program.