Novel imaging and endothelial biomarkers of small vessel cerebrovascular disease

项目摘要/摘要 小血管脑血管疾病和阿尔茨海默病是认知障碍的两个最常见的原因 老年人的下降，但确定这两种病理因素对 功能损害，了解它们之间的相互作用，预测进展和确定临床目标 试验仍然不发达。这项提议的首要目标是进一步开发新的神经成像技术。 和脑血管疾病的血清学生物标志物。实现这一目标将提高及早发现， 老年人小血管脑血管病的诊断和预后，并提供更好的靶点 以及临床试验的结果指标。我们建议纵向研究400个有良好特征的老年人。 来自加州大学旧金山分校和加州大学戴维斯分校正在进行的项目，他们表现出一系列脑血管负担和功能 拒绝。我们对生物标记物的搜索将集中在新的神经成像变量和内皮细胞的测量上 功能障碍。我们的目标是解决这些标记物和淀粉样蛋白负荷测量之间的关系， 认知，并随着时间的推移而变化。

Project Summary /Abstract Small vessel cerebrovascular disease and Alzheimer's disease are the two most common causes of cognitive decline in the elderly, but methods for determining the relative contributions of both these pathologies to functional impairment, understanding their interactions, predicting progression and defining targets for clinical trials remain underdeveloped. The overarching goal of this proposal is to further develop novel neuroimaging and serologic biomarkers of cerebrovascular disease. Accomplishing this goal will improve early detection, diagnosis, and prognosis of small vessel cerebrovascular disease in older subjects, and provide better targets and outcome metrics for clinical trials. We propose to longitudinally study 400 well characterized older subjects from ongoing projects at UCSF and UCD who present with a range of cerebrovascular burden and functional decline. Our search for biomarkers will focus on novel neuroimaging variables and measures of endothelial dysfunction. Our aims will address the relationships between these markers and measures of amyloid burden, cognition, and change over time.