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Novel imaging and endothelial biomarkers of small vessel cerebrovascular disease

小血管脑血管疾病的新型成像和内皮生物标志物

基本信息

批准号：
9768246
负责人：
Charles DeCarli
金额：
$ 118.47万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-30 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9768246
关键词：
Address Age Alzheimer&apos s Disease Amyloid Anisotropy Biological Markers Blood Blood - brain barrier anatomy Brain CXCL5 gene CXCL6 gene Cerebrovascular Disorders Cerebrum Clinical Trials Cognition Collection Communities Comorbidity DNA Data Dementia Diagnosis Diffusion Magnetic Resonance Imaging Disease Early Diagnosis Elderly Endothelial Cells Endothelium Family Functional disorder Goals IGFBP2 gene ITGB3 gene Image Impaired cognition Inflammatory Injury Integrins Lesion Longitudinal Studies Magnetic Resonance Imaging Measures Methods Microscopic Microvascular Dysfunction Modeling Multimodal Imaging Outcome Pathology Permeability Phase Phenotype Plasma Positron-Emission Tomography Process Serological Serum Signal Transduction Site Stroke Structure Testing Time Vascular Diseases Water Work base blood-based biomarker candidate marker cerebral amyloidosis cerebrovascular chemokine clinical research site cognitive ability cognitive testing cohort cytokine endothelial dysfunction executive function follow-up functional decline functional disability improved magnetic resonance imaging biomarker member mild cognitive impairment multimodality neuroimaging novel outcome forecast potential biomarker processing speed receptor standard measure validation studies white matter white matter injury

项目摘要

Project Summary /Abstract Small vessel cerebrovascular disease and Alzheimer's disease are the two most common causes of cognitive decline in the elderly, but methods for determining the relative contributions of both these pathologies to functional impairment, understanding their interactions, predicting progression and defining targets for clinical trials remain underdeveloped. The overarching goal of this proposal is to further develop novel neuroimaging and serologic biomarkers of cerebrovascular disease. Accomplishing this goal will improve early detection, diagnosis, and prognosis of small vessel cerebrovascular disease in older subjects, and provide better targets and outcome metrics for clinical trials. We propose to longitudinally study 400 well characterized older subjects from ongoing projects at UCSF and UCD who present with a range of cerebrovascular burden and functional decline. Our search for biomarkers will focus on novel neuroimaging variables and measures of endothelial dysfunction. Our aims will address the relationships between these markers and measures of amyloid burden, cognition, and change over time.

项目摘要/摘要小血管脑血管疾病和阿尔茨海默病是认知障碍的两个最常见的原因老年人的下降，但确定这两种病理因素对功能损害，了解它们之间的相互作用，预测进展和确定临床目标试验仍然不发达。这项提议的首要目标是进一步开发新的神经成像技术。和脑血管疾病的血清学生物标志物。实现这一目标将提高及早发现，老年人小血管脑血管病的诊断和预后，并提供更好的靶点以及临床试验的结果指标。我们建议纵向研究400个有良好特征的老年人。来自加州大学旧金山分校和加州大学戴维斯分校正在进行的项目，他们表现出一系列脑血管负担和功能拒绝。我们对生物标记物的搜索将集中在新的神经成像变量和内皮细胞的测量上功能障碍。我们的目标是解决这些标记物和淀粉样蛋白负荷测量之间的关系，认知，并随着时间的推移而变化。