Stem Cell Differentiation and Dedifferentiation

干细胞分化和去分化

• 批准号: 7801113
• 负责人: ANDREW D ROBERTSON
• 金额: $ 1.1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-08 至 2011-02-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7801113
• 关键词: Achievement; Address; Area; Attention; Basic Science; Cell Differentiation process; Cell Transplantation; Cells; Colorado; Development; Disease; Human; Investigation; Knowledge; Medical; Molecular; Patients; Pharmaceutical Preparations; Pluripotent Stem Cells; Regenerative Medicine; Research Personnel; Scientist; Somatic Cell; Stem Cell Research; Stem cells; Students; Techniques; Toxic effect; Toxicology; Update; cell type; clinical application; drug candidate; drug discovery; experience; human tissue; induced pluripotent stem cell; insight; interest; meetings; nuclear transfer; stem cell differentiation; symposium; tool

DESCRIPTION (provided by applicant): This proposal is to request support for a Keystone Symposia meeting entitled Stem Cell Differentiation and Dedifferentiation, organized by Shinya Yamanaka and Fiona M. Watt, which will be held in Keystone, Colorado from February 15 - 20, 2010. Recent progress in induced pluripotent stem (iPS) cells has shown that stem cells can be generated from differentiated progenies by introducing just a few defined factors. In addition, various stem cells have been isolated from human tissues. Stem cells from patients will provide various tools in understanding disease mechanisms, searching for effective drugs, and evaluating toxicity of drug candidates. Furthermore, human iPS cells and other stem cells may provide various types of cells for regenerative medicine. The Keystone Symposia meeting on Stem Cell Differentiation and Dedifferentiation will critically examine how stem cells, including iPS cells, are isolated, generated and maintained. We will also provide an update on induction of differentiated cells from stem cells. We will also discuss progress in application of pluripotent stem cells and other stem cells in basic research, drug discovery, toxicology, and regenerative medicine.

描述（由申请人提供）：本提案旨在请求支持由Shinya Yamanaka和Fiona M.瓦特，这将是在基斯通，科罗拉多从2010年2月15日至20日举行。诱导多能干细胞（iPS）的最新进展表明，干细胞可以通过引入几个确定的因子从分化的后代产生。此外，已经从人体组织中分离出各种干细胞。来自患者的干细胞将为理解疾病机制、寻找有效药物和评估候选药物的毒性提供各种工具。此外，人类iPS细胞和其他干细胞可以为再生医学提供各种类型的细胞。关于干细胞分化和去分化的Keystone研讨会将严格审查干细胞，包括iPS细胞，是如何分离，生成和维持的。我们还将提供从干细胞诱导分化细胞的最新进展。我们还将讨论多能干细胞和其他干细胞在基础研究、药物发现、毒理学和再生医学中的应用进展。