Innate Immunity Training Program

描述(申请人提供)：在过去的15年里，我们对先天免疫系统的影响和工作原理的了解呈指数级增长。先天免疫现在是一门复杂的学科，涵盖了从先天免疫受体信号到微生物发病机制到自身免疫和自体炎症疾病的各种主题。要在这样一个跨学科领域有效地培训学生，需要一个具有不同专业知识的具有凝聚力和互动性的教员单位。参加先天免疫培训计划(IITP)的28名加州大学马萨诸塞州医学院的教职员工就是这样一个群体。他们的目标是为致力于有效和创造性地扩大我们对先天免疫机制的理解的博士前学生提供一个出色的培训环境。这一目标将通过向博士前实习生提供：(1)通过UMMS核心课程和IITP课程组成部分，在生物化学/生物物理学、分子和细胞生物学、免疫学和遗传学方面具有坚实的学术背景；(2)通过额外的定期安排的期刊俱乐部、该领域国内/国际公认的专家以及IITP的学生和教师的研讨会演讲，深入了解合理的实验设计以及先天免疫系统相互作用的微妙之处；(3)利用最新技术获得创新的、具有挑战性的和专注的研究经验；(4)在机构、地方、国家和国际论坛上展示研究成果的机会；和(5)研究道德行为方面的适当培训。我们教师多样化的研究兴趣将为学员提供广泛的基础研究和翻译研究机会。教师专业知识的特殊领域包括天然宿主防御机制、病原体逃避、模式识别受体信号和相互作用(Toll样受体、Nod样受体等)、补体级联、炎症体激活、先天样淋巴细胞亚群(B1 B细胞、iNKT细胞)、蛋白质结构/功能、自身免疫和疫苗开发。我们计划每年支持10名博士前实习生(博士生和医学博士/博士生)(每名实习生5名，为期2年)。受训者将根据他们的学术成绩和之前对基础研究的承诺和天赋来选择。将特别努力招募不同的受训人员群体。培训助学金将使我们的团队能够提高学生新兵的素质，并提供一个更有凝聚力和更严格的先天免疫研究社区。

DESCRIPTION (provided by applicant): Our understanding of the impact and workings of the innate immune system has increased exponentially in the past 15 years. Innate immunity is now a complex discipline that encompasses a variety of topics ranging from innate immune receptor signaling to microbial pathogenesis to auto-immune and auto-inflammatory diseases. To effectively train students in such a cross-disciplinary field requires a cohesive and interactive faculty unit with diverse expertise. The 28 UMass Medical School faculties participating in Innate Immunity Training Program (IITP) represent just such a group. Their goal is to provide an outstanding training environment for predoctoral students committed to effectively and creatively expanding our understanding of innate immune mechanisms. This goal will be met by providing predoctoral trainees with: (1) a solid academic background in biochemistry/biophysics, molecular and cellular biology, immunology, and genetics through the UMMS core curriculum and IITP curricular components; (2) an in-depth understanding of rational experimental design as well as the subtleties of the innate immune system interactions through additional regularly scheduled journal clubs, seminar presentations by nationally/internationally recognized experts in the field, as well as by student and faculty IITP members; (3) an innovative, challenging and focused research experience using state of the art technologies; (4) opportunities to present research accomplishments at institutional, local, national and international forums; and (5) appropriate training in the ethical conduct of research. The diverse research interests of our faculty will provide trainees with a wide range of opportunities in both basic and translational research. Particular areas of faculty expertise include innate host defense mechanisms, pathogen evasion, pattern recognition receptor signaling and interactions (Toll-like receptors, NOD-like receptors, and beyond), complement cascades, inflammasome activation, innate-like lymphocyte subsets (B1 B-cells, iNKT cells), protein structure/function, autoimmunity, and vaccine development. We intend to support 10 predoctoral trainees (Ph.D and M.D./Ph.D. students) each year (5 trainees for 2 years each). Trainees will be selected based on their academic record and previous evidence of commitment and talent for basic research. Special efforts will be made to recruit a diverse group of trainees. Training grant funds will enable our group to increase the caliber of student recruits and provide an even more cohesive and rigorous innate immunity research community.