Innate Immunity Training Program

描述（由申请人提供）：在过去的15年中，我们对先天免疫系统的影响和运作的理解呈指数级增长。先天免疫现在是一门复杂的学科，涵盖了从先天免疫受体信号到微生物发病机制到自身免疫和自身炎症疾病的各种主题。要在这样一个跨学科领域有效地培养学生，需要一个具有不同专业知识的凝聚力和互动的教师单位。参加先天免疫训练计划（IITP）的马萨诸塞大学医学院的28名教员就代表了这样一个群体。他们的目标是为致力于有效和创造性地扩展我们对先天免疫机制的理解的博士生提供一个优秀的培训环境。通过UMMS核心课程和IITP课程组成部分，为博士预科生提供生物化学/生物物理学、分子和细胞生物学、免疫学和遗传学方面的坚实学术背景；(2)通过额外的定期期刊俱乐部，由国内/国际知名专家以及IITP学生和教师成员进行的研讨会演讲，深入了解理性实验设计以及先天免疫系统相互作用的微妙之处；(3)采用最先进的技术，具有创新性、挑战性和针对性的研究经验；(4)在机构、地方、国家和国际论坛上展示研究成果的机会；(5)在研究伦理行为方面的适当培训。我们教师的不同研究兴趣将为学员提供广泛的基础和转化研究机会。教师专长的特定领域包括先天宿主防御机制、病原体逃避、模式识别受体信号传导和相互作用（toll样受体、nod样受体等）、补体级联、炎性体激活、先天样淋巴细胞亚群（B1 b细胞、iNKT细胞）、蛋白质结构/功能、自身免疫和疫苗开发。我们计划支持10名博士预科生（博士和医学博士/博士）。（每年5名学员，每年2年）。受训者将根据他们的学业成绩和之前对基础研究的承诺和才能进行选择。将作出特别努力，征聘不同种类的受训人员。培训基金将使我们的团队能够提高学生招募的水平，并提供一个更有凝聚力和严格的先天免疫研究社区。

DESCRIPTION (provided by applicant): Our understanding of the impact and workings of the innate immune system has increased exponentially in the past 15 years. Innate immunity is now a complex discipline that encompasses a variety of topics ranging from innate immune receptor signaling to microbial pathogenesis to auto-immune and auto-inflammatory diseases. To effectively train students in such a cross-disciplinary field requires a cohesive and interactive faculty unit with diverse expertise. The 28 UMass Medical School faculties participating in Innate Immunity Training Program (IITP) represent just such a group. Their goal is to provide an outstanding training environment for predoctoral students committed to effectively and creatively expanding our understanding of innate immune mechanisms. This goal will be met by providing predoctoral trainees with: (1) a solid academic background in biochemistry/biophysics, molecular and cellular biology, immunology, and genetics through the UMMS core curriculum and IITP curricular components; (2) an in-depth understanding of rational experimental design as well as the subtleties of the innate immune system interactions through additional regularly scheduled journal clubs, seminar presentations by nationally/internationally recognized experts in the field, as well as by student and faculty IITP members; (3) an innovative, challenging and focused research experience using state of the art technologies; (4) opportunities to present research accomplishments at institutional, local, national and international forums; and (5) appropriate training in the ethical conduct of research. The diverse research interests of our faculty will provide trainees with a wide range of opportunities in both basic and translational research. Particular areas of faculty expertise include innate host defense mechanisms, pathogen evasion, pattern recognition receptor signaling and interactions (Toll-like receptors, NOD-like receptors, and beyond), complement cascades, inflammasome activation, innate-like lymphocyte subsets (B1 B-cells, iNKT cells), protein structure/function, autoimmunity, and vaccine development. We intend to support 10 predoctoral trainees (Ph.D and M.D./Ph.D. students) each year (5 trainees for 2 years each). Trainees will be selected based on their academic record and previous evidence of commitment and talent for basic research. Special efforts will be made to recruit a diverse group of trainees. Training grant funds will enable our group to increase the caliber of student recruits and provide an even more cohesive and rigorous innate immunity research community.