Innate Immunity Training Program

项目摘要 我们对先天免疫系统的影响和工作原理的理解 在过去的20年里呈指数级增长。先天免疫现在是一种复杂的 涵盖各种主题的学科，从先天免疫感知到 受体信号转导微生物致病机制至自身免疫和自体fl炎症 疾病。要在这样一个跨学科的fi环境中有效地培训学生，需要 具有不同专业知识的具有凝聚力和互动性的教职员工单位。28个UMASS医疗集团 参加先天免疫训练计划(IITP)的学校教职员工仅代表 这样一群人。他们的目标是为以下人员提供卓越的培训环境 博士后致力于有效和创造性地扩大我们的 了解先天免疫机制。这一目标将通过提供 博士前实习生：(1)在生物化学/生物物理学方面有坚实的学术背景， 通过UMMS核心的分子和细胞生物学、免疫学和遗传学 课程和IITP课程组成部分；(2)深入理解Rational 实验设计以及先天免疫系统相互作用的微妙之处 通过其他定期安排的期刊俱乐部，研讨会演讲由 国内/国际公认的fi领域专家，以及学生和 IITP教员；(3)创新、挑战和专注的研究体验 使用最先进的技术；(4)展示研究的机会 在机构、地方、国家和国际论坛上取得的成就；和(5) 对研究的道德行为进行适当的培训。 我们教员的不同研究兴趣将为学员提供广泛的 基础研究和翻译研究的机会。教职员工的特定领域 专业知识包括固有的宿主防御 机制、病原体逃避、模式识别受体信号和相互作用 (Toll样受体、Nod样受体等)，补体级联， 在fl淀粉体激活中，先天类淋巴细胞亚群(B1B细胞，iNKT细胞)， 蛋白质结构/功能和自身免疫。 我们打算支持6名博士前实习生(博士生或博士/博士生) 年。受训者将根据他们的学业成绩和以前的证据进行选择 对研究的投入和才华。将特别努力招聘一名多元化的 一群实习生。培训资助资金将使我们的集团能够提高 并提供更有凝聚力和更严格的先天免疫力 研究社区。

Project Summary Our understanding of the impact and workings of the innate immune system has increased exponentially in the past 20 years. Innate immunity is now a complex discipline that encompasses a variety of topics ranging from innate immune sensing and receptor signaling to microbial pathogenesis to auto-immune and auto-inflammatory diseases. To effectively train students in such a cross-disciplinary field requires a cohesive and interactive faculty unit with diverse expertise. The 28 UMass Medical School faculty participating in Innate Immunity Training Program (IITP) represent just such a group. Their goal is to provide an outstanding training environment for predoctoral students committed to effectively and creatively expanding our understanding of innate immune mechanisms. This goal will be met by providing predoctoral trainees with: (1) a solid academic background in biochemistry/biophysics, molecular and cellular biology, immunology, and genetics through the UMMS core curriculum and IITP curricular components; (2) an in-depth understanding of rational experimental design as well as the subtleties of the innate immune system interactions through additional regularly scheduled journal clubs, seminar presentations by nationally/internationally recognized experts in the field, as well as by student and faculty IITP members; (3) an innovative, challenging and focused research experience using state of the art technologies; (4) opportunities to present research accomplishments at institutional, local, national and international forums; and (5) appropriate training in the ethical conduct of research. The diverse research interests of our faculty will provide trainees with a wide range of opportunities in both basic and translational research. Particular areas of faculty expertise include innate host defense mechanisms, pathogen evasion, pattern recognition receptor signaling and interactions (Toll-like receptors,NOD-like receptors, and beyond), complement cascades, inflammasome activation, innate-like lymphocyte subsets (B1 B-cells, iNKT cells), protein structure/function, and autoimmunity. We intend to support 6 predoctoral trainees (Ph.D or M.D./Ph.D. students) each year. Trainees will be selected based on their academic record and previous evidence of commitment and talent for research. Special efforts will be made to recruit a diverse group of trainees. Training grant funds will enable our group to increase the caliber of student recruits and provide an even more cohesive and rigorous innate immunity research community.