Innate Immunity Training Program

先天免疫训练计划

• 批准号: 9151017
• 负责人: Neal Silverman
• 金额: $ 13.05万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9151017
• 关键词: Natural Immunity; Training Programs

Project Summary Our understanding of the impact and workings of the innate immune system has increased exponentially in the past 20 years. Innate immunity is now a complex discipline that encompasses a variety of topics ranging from innate immune sensing and receptor signaling to microbial pathogenesis to auto-immune and auto-inflammatory diseases. To effectively train students in such a cross-disciplinary field requires a cohesive and interactive faculty unit with diverse expertise. The 28 UMass Medical School faculty participating in Innate Immunity Training Program (IITP) represent just such a group. Their goal is to provide an outstanding training environment for predoctoral students committed to effectively and creatively expanding our understanding of innate immune mechanisms. This goal will be met by providing predoctoral trainees with: (1) a solid academic background in biochemistry/biophysics, molecular and cellular biology, immunology, and genetics through the UMMS core curriculum and IITP curricular components; (2) an in-depth understanding of rational experimental design as well as the subtleties of the innate immune system interactions through additional regularly scheduled journal clubs, seminar presentations by nationally/internationally recognized experts in the field, as well as by student and faculty IITP members; (3) an innovative, challenging and focused research experience using state of the art technologies; (4) opportunities to present research accomplishments at institutional, local, national and international forums; and (5) appropriate training in the ethical conduct of research. The diverse research interests of our faculty will provide trainees with a wide range of opportunities in both basic and translational research. Particular areas of faculty expertise include innate host defense mechanisms, pathogen evasion, pattern recognition receptor signaling and interactions (Toll-like receptors,NOD-like receptors, and beyond), complement cascades, inflammasome activation, innate-like lymphocyte subsets (B1 B-cells, iNKT cells), protein structure/function, and autoimmunity. We intend to support 6 predoctoral trainees (Ph.D or M.D./Ph.D. students) each year. Trainees will be selected based on their academic record and previous evidence of commitment and talent for research. Special efforts will be made to recruit a diverse group of trainees. Training grant funds will enable our group to increase the caliber of student recruits and provide an even more cohesive and rigorous innate immunity research community.

项目概要 我们对先天免疫系统的影响和运作的了解已经 过去20年呈指数级增长。先天免疫现在是一个复杂的 学科涵盖各种主题，从先天免疫传感到 受体信号传导至微生物发病机制至自身免疫和自身炎症 疾病。要在这样一个跨学科领域有效地培养学生，需要 具有凝聚力和互动性的教师单位，具有多样化的专业知识。 28 麻省大学医学院 参加先天免疫训练计划（IITP）的学校教师仅代表 这样的一个群体。他们的目标是为学生提供良好的培训环境 博士前学生致力于有效和创造性地扩展我们的 了解先天免疫机制。这一目标将通过提供 博士前培训生具有：（1）扎实的生物化学/生物物理学学术背景， 通过 UMMS 核心进行分子和细胞生物学、免疫学和遗传学 课程和 IITP 课程组成部分； （二）深入认识理性 实验设计以及先天免疫系统相互作用的微妙之处 通过其他定期安排的期刊俱乐部、研讨会演讲 该领域的国内/国际公认的专家以及学生和 IITP 教员成员； (3) 创新、具有挑战性和专注的研究经历 使用最先进的技术； (4) 展示研究成果的机会 在机构、地方、国家和国际论坛上取得的成就；和（5） 研究道德行为方面的适当培训。 我们教师的多元化研究兴趣将为学员提供广泛的 基础研究和转化研究的机会。特定学科领域 专业知识包括先天宿主防御 机制、病原体逃避、模式识别受体信号传导和相互作用 （Toll 样受体、NOD 样受体等）、补体级联、 炎症小体激活、先天样淋巴细胞亚群（B1 B 细胞、iNKT 细胞）、 蛋白质结构/功能和自身免疫。 我们打算每人支持 6 名博士前培训生（博士或医学博士/博士生） 年。将根据他们的学术记录和以前的证据来选择学员 对研究的承诺和天赋。将特别努力招募多元化的人才 一组实习生。培训补助资金将使我们集团能够提高 学生招募并提供更具凝聚力和严格的先天免疫力 研究社区。