Innate Immunity Training Program

项目摘要 我们对先天免疫系统的影响和工作原理的了解有所增加 在过去的25年里呈指数级增长。先天免疫现在是一门复杂的学科 包括各种主题，从先天免疫感知和受体信号到 微生物对自发性炎症和心血管疾病的致病作用。要有效地培训 在这样一个跨学科领域的学生需要一个具有凝聚力和互动性的教职员工单位 多样化的专业知识。参加先天免疫的26名美国麻省理工学院教职员工 培训计划(IITP)就是这样一个群体。我们的目标是提供卓越的 致力于有效和创造性地拓展博士后培养环境 我们对先天免疫机制的理解。这一目标将通过提供 博士前实习生：(1)在生物化学/生物物理学方面有坚实的学术背景， 分子和细胞生物学、免疫学和遗传学通过密歇根大学管理学院的核心课程 和IITP课程组成；(2)深入理解合理的实验设计 以及先天免疫系统相互作用的微妙之处 预定的期刊俱乐部，由国内/国际公认的专家进行研讨会演讲 在实地以及IITP的学生和教职员工中；(3)创新、具有挑战性和 使用最新技术的重点研究经验；(4)展示的机会 在机构、地方、国家和国际论坛上的研究成果；以及(5) 对研究的道德行为进行适当的培训。 我们教员的不同研究兴趣将为学员提供广泛的 基础研究和翻译研究的机会。教师专业知识的特定领域 包括固有寄主防御机制、病原体逃避、模式识别受体 信号和相互作用(Toll样受体、Nod样受体等)、补体 级联，炎性小体激活，先天类淋巴细胞亚群(B1 B细胞，iNKT细胞)， 蛋白质结构/功能和自身炎症性疾病。 我们计划每年支持6名博士前实习生(博士生或博士/博士生)。 实习生将根据他们的学习成绩和以前的承诺证据来选择 为研究和研究才华。将特别努力招募不同的受训人员群体。 培训助学金资金将使我们的计划能够增加学生新兵的素质，并 创建一个更严格的先天免疫研究社区。

Project Summary Our understanding of the impact and workings of the innate immune system has increased exponentially in the past 25 years. Innate immunity is now a complex discipline that encompasses a variety of topics ranging from innate immune sensing and receptor signaling to microbial pathogenesis to auto-inflammatory and cardiovascular diseases. To effectively train students in such a cross-disciplinary field requires a cohesive and interactive faculty unit with diverse expertise. The 26 UMass Medical School faculty participating in Innate Immunity Training Program (IITP) represent just such a group. Our goal is to provide an outstanding training environment for predoctoral students committed to effectively and creatively expanding our understanding of innate immune mechanisms. This goal will be met by providing predoctoral trainees with: (1) a solid academic background in biochemistry/biophysics, molecular and cellular biology, immunology, and genetics through the UMMS core curriculum and IITP curricular components; (2) an in-depth understanding of rational experimental design as well as the subtleties of the innate immune system interactions through additional regularly scheduled journal clubs, seminar presentations by nationally/internationally recognized experts in the field, as well as by student and faculty IITP members; (3) an innovative, challenging and focused research experience using state of the art technologies; (4) opportunities to present research accomplishments at institutional, local, national and international forums; and (5) appropriate training in the ethical conduct of research. The diverse research interests of our faculty will provide trainees with a wide range of opportunities in both basic and translational research. Particular areas of faculty expertise include innate host defense mechanisms, pathogen evasion, pattern recognition receptor signaling and interactions (Toll-like receptors,NOD-like receptors, and beyond), complement cascades, inflammasome activation, innate-like lymphocyte subsets (B1 B-cells, iNKT cells), protein structure/function, and autoinflammatory diseases. We intend to support 6 predoctoral trainees (Ph.D or M.D./Ph.D. students) each year. Trainees will be selected based on their academic record and previous evidence of commitment to and talent for research. Special efforts will be made to recruit a diverse group of trainees. Training grant funds will enable our program to increase the caliber of student recruits and create an even more rigorous innate immunity research community.