Innate Immunity Training Program

先天免疫训练计划

• 批准号: 10677006
• 负责人: Neal Silverman
• 金额: $ 23.67万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10677006
• 关键词: Natural Immunity; Training Programs

Project Summary Our understanding of the impact and workings of the innate immune system has increased exponentially in the past 25 years. Innate immunity is now a complex discipline that encompasses a variety of topics ranging from innate immune sensing and receptor signaling to microbial pathogenesis to auto-inflammatory and cardiovascular diseases. To effectively train students in such a cross-disciplinary field requires a cohesive and interactive faculty unit with diverse expertise. The 26 UMass Medical School faculty participating in Innate Immunity Training Program (IITP) represent just such a group. Our goal is to provide an outstanding training environment for predoctoral students committed to effectively and creatively expanding our understanding of innate immune mechanisms. This goal will be met by providing predoctoral trainees with: (1) a solid academic background in biochemistry/biophysics, molecular and cellular biology, immunology, and genetics through the UMMS core curriculum and IITP curricular components; (2) an in-depth understanding of rational experimental design as well as the subtleties of the innate immune system interactions through additional regularly scheduled journal clubs, seminar presentations by nationally/internationally recognized experts in the field, as well as by student and faculty IITP members; (3) an innovative, challenging and focused research experience using state of the art technologies; (4) opportunities to present research accomplishments at institutional, local, national and international forums; and (5) appropriate training in the ethical conduct of research. The diverse research interests of our faculty will provide trainees with a wide range of opportunities in both basic and translational research. Particular areas of faculty expertise include innate host defense mechanisms, pathogen evasion, pattern recognition receptor signaling and interactions (Toll-like receptors,NOD-like receptors, and beyond), complement cascades, inflammasome activation, innate-like lymphocyte subsets (B1 B-cells, iNKT cells), protein structure/function, and autoinflammatory diseases. We intend to support 6 predoctoral trainees (Ph.D or M.D./Ph.D. students) each year. Trainees will be selected based on their academic record and previous evidence of commitment to and talent for research. Special efforts will be made to recruit a diverse group of trainees. Training grant funds will enable our program to increase the caliber of student recruits and create an even more rigorous innate immunity research community.

项目摘要 我们对先天免疫系统的影响和运作的理解已经增加 在过去的25年里呈指数增长。先天免疫现在是一个复杂的学科， 涵盖了从先天免疫传感和受体信号传导到 微生物致病机制的自身炎症和心血管疾病。为了有效地训练 在这样一个跨学科领域的学生需要一个有凝聚力和互动的教师单位， 多样化的专业知识。麻省大学医学院的26名教师参加了先天免疫 培训计划（IITP）就是这样一个群体。我们的目标是提供一个杰出的 致力于有效和创造性地扩大博士前学生的培训环境 我们对先天免疫机制的理解这一目标将通过提供 博士前实习生：（1）生物化学/生物物理学的坚实学术背景， 分子和细胞生物学，免疫学和遗传学通过UMMS核心课程 和IITP课程组成部分;（2）深入理解合理的实验设计 以及先天免疫系统相互作用的微妙之处， 定期的期刊俱乐部，国内/国际公认的专家的研讨会演讲 在该领域，以及学生和教师IITP成员;（3）创新，具有挑战性， 使用最先进的技术进行重点研究的经验;（4）展示机会 在机构、地方、国家和国际论坛上的研究成果;以及（5） 在研究的道德行为方面进行适当的培训。 我们教师的不同研究兴趣将为学员提供广泛的 基础研究和转化研究的机会。教师专业知识的特定领域 包括先天宿主防御机制、病原体逃避、模式识别受体 信号传导和相互作用（Toll样受体、NOD样受体等），补体 级联反应、炎性小体活化、先天性样淋巴细胞亚群（B1 B细胞、iNKT细胞）， 蛋白质结构/功能和自身炎性疾病。 我们打算支持6名博士前学员（博士或医学博士/博士）。博士学生）每年。 学员将根据他们的学业成绩和以前的承诺证据进行选择 和研究的天赋。将作出特别努力，招聘各种各样的受训人员。 培训补助金将使我们的计划，以提高学生招聘的素质， 创建一个更加严格的先天免疫研究社区。

项目成果

Anti-SARS-CoV-2 Activity of Adamantanes In Vitro and in Animal Models of Infection.

• DOI: 10.3390/covid2110111
• 发表时间: 2022-11
• 期刊: COVID

TRIL is involved in cytokine production in the brain following Escherichia coli infection.

TRIL 参与大肠杆菌感染后大脑中细胞因子的产生。

• DOI: 10.4049/jimmunol.1302392
• 发表时间: 2014-08-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Wochal P;Rathinam VA;Dunne A;Carlson T;Kuang W;Seidl KJ;Hall JP;Lin LL;Collins M;Schattgen SA;MacKay CR;Fagundes CT;Carpenter S;Fitzgerald KA;O'Neill LA
• 通讯作者: O'Neill LA

Lesional CD8+ T-Cell Number Predicts Surgical Outcomes of Melanocyte-Keratinocyte Transplantation Surgery for Vitiligo.

病变 CD8 T 细胞数量可预测白癜风黑色素细胞-角质形成细胞移植手术的手术结果。

• DOI: 10.1016/j.jid.2023.03.1689
• 发表时间: 2023
• 期刊: The Journal of investigative dermatology
• 作者: Refat,MaggiA;Strassner,JamesP;Frisoli,MichaelL;Rashighi,Mehdi;Richmond,Jillian;Nada,Essam;Saleh,Ramadan;El-Hamd,MohammedAbu;Goldberg,Dori;Mahmoud,BasselH;Harris,JohnE
• 通讯作者: Harris,JohnE