Innate Immunity Training Program

先天免疫训练计划

• 批准号: 8152421
• 负责人: Neal Silverman
• 金额: $ 12.8万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8152421
• 关键词: Natural Immunity; Training Programs

DESCRIPTION (provided by applicant): Our understanding of the impact and workings of the innate immune system has increased exponentially in the past 15 years. Innate immunity is now a complex discipline that encompasses a variety of topics ranging from innate immune receptor signaling to microbial pathogenesis to auto-immune and auto-inflammatory diseases. To effectively train students in such a cross-disciplinary field requires a cohesive and interactive faculty unit with diverse expertise. The 28 UMass Medical School faculties participating in Innate Immunity Training Program (IITP) represent just such a group. Their goal is to provide an outstanding training environment for predoctoral students committed to effectively and creatively expanding our understanding of innate immune mechanisms. This goal will be met by providing predoctoral trainees with: (1) a solid academic background in biochemistry/biophysics, molecular and cellular biology, immunology, and genetics through the UMMS core curriculum and IITP curricular components; (2) an in-depth understanding of rational experimental design as well as the subtleties of the innate immune system interactions through additional regularly scheduled journal clubs, seminar presentations by nationally/internationally recognized experts in the field, as well as by student and faculty IITP members; (3) an innovative, challenging and focused research experience using state of the art technologies; (4) opportunities to present research accomplishments at institutional, local, national and international forums; and (5) appropriate training in the ethical conduct of research. The diverse research interests of our faculty will provide trainees with a wide range of opportunities in both basic and translational research. Particular areas of faculty expertise include innate host defense mechanisms, pathogen evasion, pattern recognition receptor signaling and interactions (Toll-like receptors, NOD-like receptors, and beyond), complement cascades, inflammasome activation, innate-like lymphocyte subsets (B1 B-cells, iNKT cells), protein structure/function, autoimmunity, and vaccine development. We intend to support 10 predoctoral trainees (Ph.D and M.D./Ph.D. students) each year (5 trainees for 2 years each). Trainees will be selected based on their academic record and previous evidence of commitment and talent for basic research. Special efforts will be made to recruit a diverse group of trainees. Training grant funds will enable our group to increase the caliber of student recruits and provide an even more cohesive and rigorous innate immunity research community. PUBLIC HEALTH RELEVANCE: The Innate Immunity Training Program proposed here is designed to educate the next generation of biomedical researchers in cutting-edge, high quality science. Innate immunity is of critical importance to several common human diseases including septic shock, autoimmune diseases, and nearly all infectious diseases. Trainees will receive a comprehensive classroom-based foundation in innate immunity (and allied fields) upon which their laboratory research experience will build.

描述（由申请人提供）：在过去 15 年中，我们对先天免疫系统的影响和工作原理的了解呈指数级增长。先天免疫现在是一门复杂的学科，涵盖从先天免疫受体信号传导到微生物发病机制再到自身免疫和自身炎症疾病的各种主题。为了有效地培养这样一个跨学科领域的学生，需要一个具有凝聚力和互动性、具有不同专业知识的教师单位。参加先天免疫培训计划 (IITP) 的 28 名麻省大学医学院教员就是这样一个群体。他们的目标是为致力于有效和创造性地扩展我们对先天免疫机制的理解的博士前学生提供出色的培训环境。这一目标将通过为博士前学员提供：（1）通过 UMMS 核心课程和 IITP 课程组成部分，在生物化学/生物物理学、分子和细胞生物学、免疫学和遗传学方面拥有坚实的学术背景； (2) 通过额外定期安排的期刊俱乐部、该领域的国内/国际公认专家以及学生和教师 IITP 成员的研讨会演讲，深入了解合理的实验设计以及先天免疫系统相互作用的微妙之处； (3) 使用最先进技术的创新、具有挑战性和专注的研究经验； (4) 在机构、地方、国家和国际论坛上展示研究成果的机会； (5) 研究道德行为方面的适当培训。我们教师的多元化研究兴趣将为学员提供基础和转化研究方面的广泛机会。教师专业知识的特定领域包括先天宿主防御机制、病原体逃避、模式识别受体信号传导和相互作用（Toll 样受体、NOD 样受体等）、补体级联、炎性体激活、先天样淋巴细胞亚群（B1 B 细胞、iNKT 细胞）、蛋白质结构/功能、自身免疫和疫苗开发。我们打算每年支持 10 名博士前培训生（博士和医学博士/博士生）（每 5 名培训生，为期 2 年）。将根据学员的学术记录以及之前对基础研究的承诺和才能来选择学员。将特别努力招募多元化的学员。培训资助资金将使我们小组能够提高学生招募的水平，并提供一个更有凝聚力和严谨的先天免疫研究社区。 公共健康相关性：此处提出的先天免疫培训计划旨在教育下一代生物医学研究人员掌握尖端、高质量的科学。先天免疫对于几种常见的人类疾病至关重要，包括感染性休克、自身免疫性疾病和几乎所有传染病。学员将获得先天免疫（及相关领域）的全面课堂基础知识，并在此基础上积累实验室研究经验。