Innate Immunity Training Program

描述（由申请人提供）：在过去的15年里，我们对先天免疫系统的影响和运作的理解呈指数级增长。先天免疫现在是一个复杂的学科，涵盖了从先天免疫受体信号传导到微生物发病机制到自身免疫和自身炎性疾病的各种主题。为了有效地培养学生在这样一个跨学科领域需要一个具有不同专业知识的凝聚力和互动的教师单位。麻省大学医学院的28个院系参加先天免疫训练计划（IITP）就是这样一个群体。他们的目标是为致力于有效和创造性地扩大我们对先天免疫机制的理解的博士前学生提供一个优秀的培训环境。这一目标将通过为博士前学员提供：（1）通过UMMS核心课程和IITP课程组成部分，在生物化学/生物物理学，分子和细胞生物学，免疫学和遗传学方面具有坚实的学术背景;（2）通过额外定期安排的期刊俱乐部，深入了解合理的实验设计以及先天免疫系统相互作用的微妙之处，由国内/国际公认的专家在该领域，以及学生和教师IITP成员研讨会介绍;（3）一个创新的，具有挑战性和重点的研究经验，使用最先进的技术状态;（4）在机构，地方，国家和国际论坛上展示研究成果的机会;以及（5）在研究的道德行为方面进行适当的培训。我们教师的不同研究兴趣将为学员提供基础研究和转化研究的广泛机会。教师专业知识的特定领域包括先天宿主防御机制，病原体逃避，模式识别受体信号传导和相互作用（Toll样受体，NOD样受体等），补体级联反应，炎性小体激活，先天样淋巴细胞亚群（B1 B细胞，iNKT细胞），蛋白质结构/功能，自身免疫和疫苗开发。我们打算支持10名博士前学员（博士和医学博士/博士学生）（5名学员，每两年）。学员将根据他们的学业成绩和以前的承诺和基础研究的人才证据进行选择。将作出特别努力，招聘各种各样的受训人员。培训补助金将使我们的团队能够提高学生的素质，并提供一个更有凝聚力和更严格的先天免疫研究社区。

DESCRIPTION (provided by applicant): Our understanding of the impact and workings of the innate immune system has increased exponentially in the past 15 years. Innate immunity is now a complex discipline that encompasses a variety of topics ranging from innate immune receptor signaling to microbial pathogenesis to auto-immune and auto-inflammatory diseases. To effectively train students in such a cross-disciplinary field requires a cohesive and interactive faculty unit with diverse expertise. The 28 UMass Medical School faculties participating in Innate Immunity Training Program (IITP) represent just such a group. Their goal is to provide an outstanding training environment for predoctoral students committed to effectively and creatively expanding our understanding of innate immune mechanisms. This goal will be met by providing predoctoral trainees with: (1) a solid academic background in biochemistry/biophysics, molecular and cellular biology, immunology, and genetics through the UMMS core curriculum and IITP curricular components; (2) an in-depth understanding of rational experimental design as well as the subtleties of the innate immune system interactions through additional regularly scheduled journal clubs, seminar presentations by nationally/internationally recognized experts in the field, as well as by student and faculty IITP members; (3) an innovative, challenging and focused research experience using state of the art technologies; (4) opportunities to present research accomplishments at institutional, local, national and international forums; and (5) appropriate training in the ethical conduct of research. The diverse research interests of our faculty will provide trainees with a wide range of opportunities in both basic and translational research. Particular areas of faculty expertise include innate host defense mechanisms, pathogen evasion, pattern recognition receptor signaling and interactions (Toll-like receptors, NOD-like receptors, and beyond), complement cascades, inflammasome activation, innate-like lymphocyte subsets (B1 B-cells, iNKT cells), protein structure/function, autoimmunity, and vaccine development. We intend to support 10 predoctoral trainees (Ph.D and M.D./Ph.D. students) each year (5 trainees for 2 years each). Trainees will be selected based on their academic record and previous evidence of commitment and talent for basic research. Special efforts will be made to recruit a diverse group of trainees. Training grant funds will enable our group to increase the caliber of student recruits and provide an even more cohesive and rigorous innate immunity research community.