Integrated, Interdisciplinary, Inter-university PHD Program Computational Biology

描述（由申请人提供）：近年来，生物医学研究的实践经历了巨大的变化，主要是受高通量数据生成的新生物技术的推动。这些技术包括成像、基因测序、蛋白质组学、结构测定和许多其他任务的高通量方法，这些技术现在可以从分子到有机体水平精细地表征生命系统的许多方面。生物技术的这些进步及其产生的大量数据使生物医学研究发生了革命性的变化。然而，它们也产生了对科学家的迫切需求，这些科学家能够在一个越来越多的数据驱动和依赖于先进计算方法的领域工作。特别是，现代生物医学研究依赖于一种新型的计算和数学复杂的研究人员，他们能够理解新的生物技术，开发创新的数学模型和计算机算法，以使其数据有意义，并应用这些知识来推动生物学和医学的进步。要做到这一点，这些研究人员需要对计算科学、他们所从事的生物医学应用以及为他们提供信息的生物和物理科学有很强的掌握。卡耐基梅隆大学/匹兹堡大学计算生物学博士课程（CPCB）是为了满足培养计算生物学专家的需求而创建的。该计划旨在培养计算生物学的未来领导者：具有深厚计算理论，生物和物理科学知识的研究科学家，以及这些领域交叉的专业跨学科知识的不断增长的机构。为了实现这一目标，该计划利用了其两个主办机构的共同优势，这些机构在计算机科学、工程和医学研究方面共同处于世界领先地位，在计算生物学研究和教育方面有着长期的创新记录。培训计划包括一个创新的课程，涵盖了广泛定义的计算生物学基础，以及大量的高级选修课程，涵盖了计算生物学研究的四个广泛领域：生物图像信息学、细胞和系统建模、计算基因组学和计算结构生物学。项目学生在计算生物学研究前沿的众多实验室中进行论文研究。这些课程作业和论文研究的主要组成部分由许多机制补充，以促进学生的成功，促进专业发展，鼓励负责任的研究行为，并帮助招募和留住代表性不足的群体。拟议的项目旨在为更广泛的CPCB研究生项目中的一部分学生提供新的培训支持。它将为最有前途的学生提供两年的研究支持，为他们提供额外的资源和灵活性，以追求最具创新性的研究方向，并帮助他们发展成为计算生物学和生物医学研究的未来领导者。

DESCRIPTION (provided by applicant): The practice of biomedical research has undergone dramatic changes in recent years, largely driven by new biotechnology for high-throughput data generation. These technologies include high-throughput methods for imaging, genetic sequencing, proteomics, structure determination, and numerous other tasks that now make it possible to finely characterize numerous aspects of living systems from the molecular to the organismal levels. These advances in biotechnology and the vast amounts of data they are producing have revolutionized biomedical research. They have also, however, created a pressing need for scientists capable of working in a field that is increasingly data-driven and dependent on advanced computational methods. In particular, modern biomedical research depends on a new breed of computationally and mathematically sophisticated researchers who can understand new biotechnologies, develop innovative mathematical models and computer algorithms needed to make sense of their data, and apply this knowledge to drive biological and medical advances. To do so, these researchers require a strong command of computational science, the biomedical applications on which they work, and the biological and physical sciences that inform them. The Carnegie Mellon University/University of Pittsburgh Ph.D. Program in Computational Biology (CPCB) was created to meet this need for training experts in computational biology. The program aims to prepare the future leaders of computational biology: research scientists with deep knowledge of computational theory, biological and physical sciences, and a growing body of specialized interdisciplinary knowledge at the intersection of these areas. To accomplish this, the program leverages the shared strengths of its two hosts institutions, collectively world leaders in computer science, engineering, and medical research with long track records of innovation in computational biology research and educational. The training program includes an innovative curriculum covering fundamentals of computational biology, broadly defined, and a large body of advanced elective coursework spanning four broad domains of computational biology research: bioimage informatics, cellular and systems modeling, computational genomics, and computational structural biology. Program students perform thesis research in any of numerous laboratories at the cutting edge of computational biology research. These primary components of coursework and thesis research are supplemented by numerous mechanisms to facilitate student success, promote professional development, encourage responsible conduct of research, and aid in recruiting and retaining underrepresented groups. The proposed program seeks to renew training support for a select subset of students in the broader CPCB graduate program. It will provide the most promising students with two years of research support, providing them added resources and flexibility to pursue the most innovative research directions and to aid in their development into future leaders of computational biology and biomedical research as a whole.