Cytokine JAK-STAT Signaling in Immunity and Disease

 描述（由申请人提供）：请求支持由Curt M.组织的题为免疫和疾病中的细胞因子JAK-STAT信号传导的Keystone研讨会会议。作者声明：John J.瓦托维奇会议将于2016年1月10日至15日在科罗拉多的汽船泉举行。细胞因子是重要的细胞外因子，在正常生理和疾病中指导各种生物反应。细胞因子信号传导在很大程度上通过四种Janus激酶（JAK）蛋白和七种信号转导和转录激活因子（STAT）蛋白介导，并且这些分子与大量额外的细胞内信号交叉以驱动基因表达的显著全局改变。细胞因子JAK-STAT通路与先天和适应性免疫、炎症、干细胞和发育生物学以及癌症生物学的各个方面密切相关。由于JAK-STAT途径产生对广泛的生物现象至关重要的共同和独特的表型，因此通过发现一般和途径特异性机制，对这些信号转导级联如何调节、发挥功能并与其他细胞反应整合的基本理解不断得到完善。此外，药物发现工作已经产生了靶向JAK和STAT的小分子，这些小分子在炎症、关节炎和各种癌症的临床治疗中是有前途的药剂。本次会议恰逢JAK-STAT信号转导发现的第25个年头，将邀请对相关学科做出重大贡献的演讲者与细胞因子JAK-STAT退伍军人和该领域的新人，并有充分的机会从提交的摘要中选择简短的演讲。

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Cytokine JAK-STAT Signaling in Immunity and Disease, organized by Curt M. Horvath, John J. O'Shea and Stephanie S. Watowich. The meeting will be held in Steamboat Springs, Colorado from January 10-15, 2016. Cytokines are important extracellular factors that direct a variety of biological responses in normal physiology and disease. Cytokine signaling is mediated in large part through four Janus kinase (JAK) proteins and seven Signal Transducer and Activator of Transcription (STAT) proteins, and these molecules intersect with a wide array of additional intracellular signals to drive significant global alterations in gene expression. Cytokine JAK-STAT pathways are intimately associated with innate and adaptive immunity, inflammation, stem cell and developmental biology, and diverse aspects of cancer biology. As JAK-STAT pathways produce both common and unique phenotypes critical for a vast range of biological phenomena, the basic understanding of how these signal transduction cascades are regulated, function and integrate with additional cellular responses has been continuously refined by discoveries of general and pathway-specific mechanisms. Furthermore, drug discovery efforts have produced small molecules targeting JAKs and STATs that are promising agents in clinical treatment of inflammation, arthritis and a variety of cancers. This meeting, coinciding with the 25th year of the discovery of JAK-STAT signaling, will couple invited speakers who have made significant contributions to allied disciplines with both cytokine JAK-STAT veterans and newcomers to the field, with ample opportunities for short talks selected from submitted abstracts.