New Frontiers in Understanding Tumor Metabolism

 描述（由申请人提供）：请求支持由Chi货车Dang、Katharine Yen和Navdeep S.钱德尔会议将于2016年2月21日至26日在加拿大阿尔伯塔省班夫市举行。本次会议将汇集该领域的专家以及新来者，他们有望丰富肿瘤代谢研究的概念框架。全体会议旨在为生物学家带来最新的代谢基础生物化学工作，提供代谢的致癌转录和转录后调控的新发现，作为进一步基础生物化学发现的基础，并提供导致肿瘤代谢研究的治疗应用的基础发现。这些会议将允许与会者讨论先前未被怀疑的癌症代谢重新布线的新发现，并介绍肿瘤代谢的转录和转录后调控的当前发现以及未来的挑战。会议还将提供关于利用基础发现产生的知识进行癌症治疗的机会的最新信息。新的方法和知识将在会议上分享，跨学科互动的机会将通过免疫功能和炎症性疾病中的免疫代谢同时举行的会议显着增强，该会议将与本次会议分享主题演讲和全体会议。NCI在资助推动肿瘤代谢领域向前发展的研究方面一直处于NIH研究所的最前沿。最近，NCI与NIH共同基金合作，支持与肿瘤生物学和人类癌症相关的代谢组学研究。由于肿瘤代谢作为一个领域对我们理解癌症的发生和发展至关重要，NCI是支持本次会议主题的最相关的NIH研究所。该会议将大大推进我们对肿瘤代谢的理解，并将有助于为癌症预防，癌症检测和癌症治疗的新方法提供框架。

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled New Frontiers in Understanding Tumor Metabolism, organized by Chi Van Dang, Katharine Yen and Navdeep S. Chandel. The meeting will be held in Banff, Alberta, Canada from February 21-26, 2016. This meeting will bring together experts in the field as well as newcomers, who are expected to enrich the conceptual framework for the study of tumor metabolism. Plenary sessions are designed to bring the latest in basic biochemical work in metabolism to biologists, to deliver new findings in oncogenic transcriptional and post-transcriptional regulation of metabolism as a basis for further basic biochemical discoveries, and to provide foundational findings that lead to therapeutic applications of tumor metabolism research. These sessions will allow attendees to discuss new discoveries of previously unsuspected metabolic re-wiring in cancer and present current findings in transcriptional and post- transcriptional regulation of tumor metabolism and future challenges. The sessions will also provide an update on opportunities for cancer therapy using knowledge generated from fundamental discoveries. New methods and knowledge will be shared at the meeting, and opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Immunometabolism in Immune Function and Inflammatory Disease, which will share a keynote address and plenary session with this meeting. NCI has been at the forefront of NIH Institutes in funding research that propels the field of tumor metabolism forward. More recently, NCI has partnered with the NIH Common Fund to support studies on metabolomics that are relevant to tumor biology and human cancers. Since tumor metabolism as a field is vital to our understanding of cancer initiation and progression, NCI is the most relevant NIH Institute to support this meeting topic. The conference will significantly advance our understanding of tumor metabolism and will help provide the framework for new approaches to cancer prevention, cancer detection, and cancer therapy.