New Frontiers in Understanding Tumor Metabolism

 描述(由申请者提供)：请求支持由ChiVan Dang、Katharine Yen和NavDeep S.Chandel组织的题为了解肿瘤代谢的新前沿的Keystone研讨会。会议将于2016年2月21日至26日在加拿大艾伯塔省班夫举行。这次会议将汇聚该领域的专家以及新来者，他们有望丰富肿瘤代谢研究的概念框架。全体会议旨在向生物学家介绍代谢方面的最新基础生化工作，提供致癌转录和转录后代谢调控方面的新发现，作为进一步基础生化发现的基础，并提供导致肿瘤代谢研究治疗应用的基础发现。这些会议将允许与会者讨论以前未被怀疑的癌症代谢重新连接的新发现，并介绍目前在转录和转录后调节肿瘤新陈代谢方面的发现和未来的挑战。这些会议还将提供利用基础发现产生的知识进行癌症治疗的机会的最新情况。会议将分享新的方法和知识，同时召开的免疫功能和炎症性疾病免疫代谢会议将大大增加跨学科互动的机会，该会议将与本次会议举行主题演讲和全体会议。NCI在资助推动肿瘤新陈代谢领域向前发展的研究方面一直走在NIH研究所的前列。最近，NCI与NIH共同基金合作，支持与肿瘤生物学和人类癌症相关的代谢组学研究。由于肿瘤代谢作为一个领域对我们理解癌症的发生和发展是至关重要的，NCI是支持这一会议主题的最相关的NIH研究所。这次会议将极大地促进我们对肿瘤代谢的了解，并将有助于为癌症预防、癌症检测和癌症治疗提供新的方法框架。

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled New Frontiers in Understanding Tumor Metabolism, organized by Chi Van Dang, Katharine Yen and Navdeep S. Chandel. The meeting will be held in Banff, Alberta, Canada from February 21-26, 2016. This meeting will bring together experts in the field as well as newcomers, who are expected to enrich the conceptual framework for the study of tumor metabolism. Plenary sessions are designed to bring the latest in basic biochemical work in metabolism to biologists, to deliver new findings in oncogenic transcriptional and post-transcriptional regulation of metabolism as a basis for further basic biochemical discoveries, and to provide foundational findings that lead to therapeutic applications of tumor metabolism research. These sessions will allow attendees to discuss new discoveries of previously unsuspected metabolic re-wiring in cancer and present current findings in transcriptional and post- transcriptional regulation of tumor metabolism and future challenges. The sessions will also provide an update on opportunities for cancer therapy using knowledge generated from fundamental discoveries. New methods and knowledge will be shared at the meeting, and opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Immunometabolism in Immune Function and Inflammatory Disease, which will share a keynote address and plenary session with this meeting. NCI has been at the forefront of NIH Institutes in funding research that propels the field of tumor metabolism forward. More recently, NCI has partnered with the NIH Common Fund to support studies on metabolomics that are relevant to tumor biology and human cancers. Since tumor metabolism as a field is vital to our understanding of cancer initiation and progression, NCI is the most relevant NIH Institute to support this meeting topic. The conference will significantly advance our understanding of tumor metabolism and will help provide the framework for new approaches to cancer prevention, cancer detection, and cancer therapy.