Pathways to Diabetes Prevention

预防糖尿病的途径

• 批准号: nhmrc : 535921
• 负责人: Prof David James
• 金额: $ 746.85万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Programs
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pathways-diabetes-prevention/94536
• 关键词: Pathways; Diabetes; Prevention

Type 2 diabetes (T2D) is threatening the health of this nation and if unchecked will cripple our health care system. There are several problems: (1) The incidence of T2D is growing and we do not fully know why; (2) T2D involves defective insulin action but how insulin works normally is still unclear; (3) much research in this area is performed in laboratory cells or animals and the translation of this research to the human disease is yet to be fully realised; and (4) current therapies and diagnostic markers for early disease prediction are inadequate. Our goal is to make progress in each of these areas.

2型糖尿病(T2D)正在威胁这个国家的健康，如果不加以控制，将使我们的医疗保健系统陷入瘫痪。有几个问题：(1)T2D的发病率正在增加，我们不完全知道原因；(2)T2D涉及胰岛素作用缺陷，但胰岛素如何正常工作仍不清楚；(3)这一领域的许多研究是在实验室细胞或动物中进行的，这种研究尚未完全实现；以及(4)目前用于早期疾病预测的治疗和诊断标记物不足。我们的目标是在这些领域中的每一个方面取得进展。