Mechanistic studies of c-Cbl - a modulator of energy homeostasis.
Mechanistic studies of c-Cbl - a modulator of energy homeostasis.
批准号:
nhmrc : 325624
负责人:
Prof David James
金额:
$30.31万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2005
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2005-01-01 至 2007-12-31
中文摘要
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英文摘要
Obesity has become one of the most serious health care problems in the world. It is a problem not just because more people are getting fatter. It is a problem because obesity is a major risk factor for many other diseases including Type 2 diabetes and heart disease. While many consider the solution to be straight forward, ie eat less, this is obviously not an effective solution because the problem is accelerating at lightning speed around the world. At the Garvan Institute we have recently identified a new mouse model bearing a disruption in one single gene. This mouse eats 30% more food than its siblings but has half the body fat. This exciting discovery constitutes the foundation for the present proposal.
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