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Unravelling a canonical mitochondrial stress response pathway

Unravelling a canonical mitochondrial stress response pathway
揭示典型的线粒体应激反应途径
批准号:
DP210102099
负责人:
Prof David James
金额:
$38.36万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2021
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2021-01-01 至 2023-12-31

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中文摘要
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英文摘要
Stress has a major impact on all life forms and is considered one of the key determinants of healthy ageing. This project aims to unravel a highly novel pathway through which many different forms of stress converge to induce a conserved stress response in mammalian cells. Major outcomes include rewriting the textbook on how stress is sensed by cells and how cells respond to this stress and will provide novel approaches and technologies for studying stress in a broad range of organisms and systems. This project will benefit all efforts to understand stress and aid efforts by others to ameliorate stress-mediated health defects across the animal kingdom
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Mapping the genetic and lifestyle landscape of Healthy Ageing
  • 批准号:
    FL200100096
  • 项目类别:
    Australian Laureate Fellowships
  • 资助金额:
    $239.5万
  • 财政年份:
    2021
  • 负责人:
    Prof David James
  • 依托单位:
Integrated Multimodal System for Multiplexed Imaging of Signal Transduction
  • 批准号:
    LE210100011
  • 项目类别:
    Linkage Infrastructure, Equipment and Facilities
  • 资助金额:
    $60.01万
  • 财政年份:
    2021
  • 负责人:
    Prof David James
  • 依托单位:
Novel regulatory mechanisms for the protein kinase Akt
  • 批准号:
    DP180103482
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $37.13万
  • 财政年份:
    2018
  • 负责人:
    Prof David James
  • 依托单位:
Probing the Gene-Environment Interaction in Metabolic Disease
  • 批准号:
    nhmrc : GNT1117078
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $86.39万
  • 财政年份:
    2017
  • 负责人:
    Prof David James
  • 依托单位:
国内基金
海外基金
非经典BAF(non-canonical BAF,ncBAF)复合物在小鼠胚胎干细胞中功能及其分子机理的研究
  • 批准号:
    32170797
  • 项目类别:
    面上项目
  • 资助金额:
    58万元
  • 批准年份:
    2021
  • 负责人:
    张文胜
  • 依托单位:
泛素连接酶Nedd4l对非经典NF-kappaB信号途径的调节作用
力学负荷与ERa\Wnt相互作用调节骨代谢的细胞分子机理研究
  • 批准号:
    30770534
  • 项目类别:
    面上项目
  • 资助金额:
    28.0万元
  • 批准年份:
    2007
  • 负责人:
    李良
  • 依托单位:
Hall代数与canonical基
  • 批准号:
    19971060
  • 项目类别:
    面上项目
  • 资助金额:
    17.0万元
  • 批准年份:
    1999
  • 负责人:
    彭联刚
  • 依托单位: