Dissection of Insulin Regulated Phosphorylation in the Adipocyte

点击翻译按钮获取中文摘要

Obesity and diabetes are increasing at an alarming rate throughout the world. These diseases are part of a constellation of disorders that includes cardiovascular disease and kidney disease, which are collectively referred to as the metabolic syndrome. A disorder referred to as insulin resistance is at the heart of the metabolic syndrome. This represents the inability of insulin to function correctly in target cells like muscle and fat. In this project we are attempting to undertake a large scale effort to understand the complex circuitry that gets turned on within cells when they become exposed to insulin. This project involves a collaboration between the Garvan Institute and the University of New South Wales Mass Spectrometry Facility allowing us to bring a combination of very sophisticated technologies to bear on this very significant health care problem. This project will provide major new insights into our understanding of insulin action yielding new possibilities for therapeutic development.