Mapping the genetic and lifestyle landscape of Healthy Ageing

绘制健康老龄化的遗传和生活方式图谱

• 批准号: FL200100096
• 负责人: Prof David James
• 金额: $ 239.5万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-08-02 至 2026-08-01
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FL200100096
• 关键词: Mapping; genetic; lifestyle; landscape; Healthy

This project aims to dissect how genes interact with the environment to control healthy ageing using a multidisciplinary approach combining state-of-the-art omics technologies, metabolic and ageing phenotyping and genetic analysis and a highly diverse model system. The project is expected to establish fundamental new understanding of the ageing process by identifying genes that regulate ageing either alone or in response to diet; by defining the mechanism by which such genes control ageing and by identifying biomarkers that predict different ageing outcomes. This knowledge will contribute to future strategies based on genetic testing and biomarkers to optimise healthy ageing in humans.

该项目旨在剖析基因如何与环境相互作用，以控制健康老龄化，使用多学科方法，结合最先进的组学技术，代谢和衰老表型和遗传分析以及高度多样化的模型系统。该项目预计将通过确定单独或对饮食作出反应的调节衰老的基因，确定这些基因控制衰老的机制，并确定预测不同衰老结果的生物标志物，从而对衰老过程建立根本性的新认识。这些知识将有助于未来基于基因检测和生物标志物的策略，以优化人类的健康老龄化。